N/A N=6 Other

Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Catecholaminergic Polymorphic Ventricular Tachycardia

Bottom Line

View on ClinicalTrials.gov: NCT02927223 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2020

Primary outcome: Primary: Number of Ventricular Ectopic Beats Recorded During Exercise (and Recovery) — 46; 0 number of ventricular beats

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Atropine (Drug); Exercise treadmill test (Procedure)
Age: Pediatric, Adult, Older Adult · 6+ yrs
Sex: All
Sponsor: Vanderbilt University
Primary completion: Feb 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Ventricular Ectopic Beats Recorded During Exercise (and Recovery)	46; 0	—

Summary

To test the hypothesis that increasing the sinus node rate with atropine treatment prior to exercise will reduce exercise-triggered ventricular ectopy compared to baseline in patients with CPVT.

Eligibility Criteria

Inclusion Criteria

Age >/= 6 years
Able to provide written informed consent
Clinical diagnosis of CPVT
Able to exercise on a treadmill
Successful completion of a minimum of 2 exercise stress tests without adverse events

Exclusion Criteria

Contraindication to treadmill stress testing according to Vanderbilt University Medical Center's clinical protocols (unstable angina, decompensated congestive heart failure, severe hypertension (≥ 170/90 mmHg), acute myocardial infarction (<4 days), moderate to severe aortic stenosis, acute pulmonary embolism, severe pulmonary hypertension, outflow tract obstruction, hypertrophic cardiomyopathy, left main coronary stenosis, left bundle branch block)
Females who are pregnant
In the judgement of the investigator, any clinically significant ongoing medical or surgical condition that might jeopardize the subject's safety or interfere with the conduct of the study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02927223). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.