N/A
N=168
A Study Examining Adolescents With Non-Suicidal Self-Injury
Self-Injurious Behavior · Deliberate Self-Harm
Bottom Line
View on ClinicalTrials.gov: NCT02947308 ↗Enrolled (actual)
168
Serious AEs
0.6%
Results posted
Mar 2026
Primary outcome: Primary: Self-Injurious Thoughts and Behaviors Interview (SITBI) - Lifetime Episodes — 73.29; 0 episode count
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Pediatric · 12+ yrs
- Sex
- Female
- Sponsor
- University of Minnesota
- Primary completion
- Jul 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Lifetime Episodes |
141.04; 28.79 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Year Episodes |
8.13; 1.47 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Month Episodes |
0.46; 1.67 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Lifetime Episodes |
141.04; 28.79 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Year Episodes |
8.13; 1.47 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Month Episodes |
0.46; 1.67 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Lifetime Episodes |
141.04; 28.79 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Year Episodes |
8.13; 1.47 | — |
| PRIMARY Self-Injurious Thoughts and Behaviors Interview (SITBI) - Past Month Episodes |
0.46; 1.67 | — |
| SECONDARY Salivary Cortisol Response to Stress |
-0.21; 0.85 | — |
| SECONDARY Salivary Cortisol Response to Stress |
-0.21; 0.85 | — |
| SECONDARY Salivary Cortisol Response to Stress |
-0.21; 0.85 | — |
| SECONDARY Beck Scale for Suicidal Ideation (BSSI) |
3.51; 0.6 | — |
| SECONDARY Beck Scale for Suicidal Ideation (BSSI) |
3.51; 0.6 | — |
| SECONDARY Beck Scale for Suicidal Ideation (BSSI) |
3.51; 0.6 | — |
| SECONDARY Beck Depression Inventory |
16.77; 7.07 | — |
| SECONDARY Beck Depression Inventory |
16.77; 7.07 | — |
| SECONDARY Beck Depression Inventory |
16.77; 7.07 | — |
| SECONDARY Personality Assessment Inventory, Adolescent Form (PAI-A) |
49.78; 45.5 | — |
| SECONDARY Personality Assessment Inventory, Adolescent Form (PAI-A) |
49.78; 45.5 | — |
| SECONDARY Personality Assessment Inventory, Adolescent Form (PAI-A) |
49.78; 45.5 | — |
| SECONDARY SPPA, Global Self-worth |
2.45; 3.05 | — |
| SECONDARY SPPA, Global Self-worth |
2.45; 3.05 | — |
| SECONDARY SPPA, Global Self-worth |
2.45; 3.05 | — |
| SECONDARY Urgency, Premeditation, Perseverance, Sensation Seeking, and Positive Urgency (UPPS-P) |
2.47; 1.67 | — |
| SECONDARY Urgency, Premeditation, Perseverance, Sensation Seeking, and Positive Urgency (UPPS-P) |
2.47; 1.67 | — |
| SECONDARY Urgency, Premeditation, Perseverance, Sensation Seeking, and Positive Urgency (UPPS-P) |
2.47; 1.67 | — |
| SECONDARY D-prime (d') Values Representing Response-inhibition Performance on the Emotional Go/NoGo Task |
0.85; 1 | — |
| SECONDARY D-prime (d') Values Representing Response-inhibition Performance on the Emotional Go/NoGo Task. |
1.09; 1.12 | — |
| SECONDARY D-prime (d') Values Representing Response-inhibition Performance on the Emotional Go/NoGo Task. |
1.09; 1.12 | — |
| SECONDARY Self-Network Cortical Thickness (Structural MRI) |
3.08; 3.08 | — |
| SECONDARY Self-Network Cortical Thickness (Structural MRI) |
3.08; 3.08 | — |
| SECONDARY Self-Network Cortical Thickness (Structural MRI) |
3.08; 3.08 | — |
| SECONDARY Cognitive Control Network Cortical Thickness and Subcortical Volume (Structural MRI) |
3.23; 3.22 | — |
| SECONDARY Cognitive Control Network Cortical Thickness and Subcortical Volume (Structural MRI) |
3.23; 3.22 | — |
| SECONDARY Cognitive Control Network Cortical Thickness and Subcortical Volume (Structural MRI) |
3.23; 3.22 | — |
| SECONDARY Amygdala Volume (Structural MRI) |
1527.2; 1577.95 | — |
| SECONDARY Amygdala Volume (Structural MRI) |
1527.2; 1577.95 | — |
| SECONDARY Amygdala Volume (Structural MRI) |
1527.2; 1577.95 | — |
| SECONDARY Bilateral Self-Network Task fMRI Activation During Negative vs Positive Evaluation Conditions of the Self vs Change Task |
0.44; 0.09 | — |
| SECONDARY Bilateral Self-Network Task fMRI Activation During Negative vs Positive Evaluation Conditions of the Self vs Change Task |
0.44; 0.09 | — |
| SECONDARY Bilateral Self-Network Task fMRI Activation During Negative vs Positive Evaluation Conditions of the Self vs Change Task |
0.44; 0.09 | — |
| SECONDARY Bilateral Cognitive Control Network Task fMRI Activation During Inhibition in Negative Contexts Versus Scrambled Contexts in the Go/No-Go Task |
0.10; 0.03 | — |
| SECONDARY Bilateral Cognitive Control Network Task fMRI Activation During Inhibition in Negative Contexts Versus Scrambled Contexts in the Go/No-Go Task |
0.10; 0.03 | — |
| SECONDARY Bilateral Cognitive Control Network Task fMRI Activation During Inhibition in Negative Contexts Versus Scrambled Contexts in the Go/No-Go Task |
0.10; 0.03 | — |
| SECONDARY Bilateral Amygdala Activation to the Negative Face vs Shape (Threat) Condition of the Emotional Face Matching Task |
2.59; 2.35 | — |
| SECONDARY Bilateral Amygdala Activation to the Negative Face vs Shape (Threat) Condition of the Emotional Face Matching Task |
2.59; 2.35 | — |
| SECONDARY Bilateral Amygdala Activation to the Negative Face vs Shape (Threat) Condition of the Emotional Face Matching Task |
2.59; 2.35 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Resting-state Functional Connectivity Within the Cognitive Control Network |
0.23; 0.27 | — |
| SECONDARY Resting-state Functional Connectivity Within the Cognitive Control Network |
0.23; 0.27 | — |
| SECONDARY Resting-state Functional Connectivity Within the Cognitive Control Network |
0.23; 0.27 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Resting-state Functional Connectivity Within Anterior and Posterior Nodes of the Self Network |
0.03; 0.05 | — |
| SECONDARY Timeline Followback |
11.31; 0 | — |
| SECONDARY Timeline Followback |
11.31; 0 | — |
| SECONDARY Timeline Followback |
11.31; 0 | — |
Summary
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI). Specifically, three constructs outlined by the Research Domains Criteria (RDoC) will be examined through self-assessment, MRI, and a cognitive battery.
Eligibility Criteria
Inclusion Criteria
- 12-16 years old
- Female
- Has had first menstruation
- Willingness to have de-identified data shared with RDoC database
Inclusion Criteria - Adolescents with Non-Suicidal Self-Injury:
- Any history of self harm
Inclusion Criteria - Healthy Controls:
- No history of self harm
Exclusion Criteria
- Male
- Pregnancy
- MRI Incompatibility
- IQ of less than 80
- Major Medical Illness
- Diagnosis of any of the following: Primary Psychotic Disorder, Bipolar Spectrum Disorder, Autism Spectrum Disorder, Current or Past Substance Use Disorder
Data sourced from ClinicalTrials.gov (NCT02947308). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.