Phase 3
Completed N=46
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
Aggressive Periodontitis
Source: ClinicalTrials.gov NCT02969928 ↗
Enrolled (actual)
46
Serious AEs
0.0%
Results posted
Sep 2020
Primary outcomePrimary: Change in Clinical Attachment Level (CAL) — 3.69; 3.62; 2.4; 3 mm
◆ Published Evidence
Established
93citations · ~16 / year
Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis.
Summary
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis (GAgP).
Linked Publications (2)
-
Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis.
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Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Clinical Attachment Level (CAL) |
3.69; 3.62; 2.4; 3; 3; 3 | — |
| SECONDARY Change in Probing Depth (PB) |
3.44; 3.41; 2.5; 2.7; 2.6; 2.7 | — |
| SECONDARY Change in Bleeding on Probe (BoP) |
53.4; 43.7; 30.2; 24.8; 27.3; 23.3 | — |
Eligibility Criteria
Inclusion Criteria
- diagnosis of GAgP (AAP, 1999);
- presence of ≥20 teeth;
- presence of ≥ 6 sites presenting PD ≥ 5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to other two non-contiguous teeth);
- good general health;
- ≤ 35 years old; and
- agree to participate in the study and sign a written informed consent. All subjects will be individually informed about the objectives, probable risks and benefits of the protocol treatment (according to Resolution nº196 of October 1996 and to the Professional Code of Dental Ethics - 179/93).
Exclusion Criteria
- pregnancy or lactating;
- suffer from any systemic disease (e.g. cardiovascular disorders, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease;
- took antimicrobials in the previous 6 months;
- taking long-term anti-inflammatory drugs;
- previous periodontal treatment within the last 12 months;
- smokers.
Data sourced from ClinicalTrials.gov (NCT02969928) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.