N/A
N=114
Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
Cardiogenic Pulmonary Oedema
Bottom Line
View on ClinicalTrials.gov: NCT02977572 ↗Enrolled (actual)
114
Serious AEs
—
Results posted
Jul 2017
Primary outcome: Primary: Need for an Endotracheal Intubation Within Seven Days After Onset of Cardiopulmonary Edema at the Intensive Care Unit — 5; 5 Participants — p=1.000
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Non-Invasive Ventilation (Device); Continuous Positive AirwayPressure CPAP (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Hospital General Universitario de Castellón
- Primary completion
- Dec 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Need for an Endotracheal Intubation Within Seven Days After Onset of Cardiopulmonary Edema at the Intensive Care Unit |
5; 5 | 1.000 |
| SECONDARY Duration of the Ventilation |
16; 10 | — |
| SECONDARY Ventilator Acquired Pneumonia |
3; 1 | — |
| SECONDARY Acute Renal Failure |
12; 13 | — |
| SECONDARY Length of Stay at Intensive Care Unit |
3; 4 | — |
| SECONDARY Length of Hospital Stay |
12; 14 | — |
| SECONDARY Intensive Care Unit Mortality |
12; 14 | — |
| SECONDARY 28th Day Mortality |
13; 16 | — |
| SECONDARY Hospital Mortality |
15; 17 | — |
Summary
The aim of the present study was to demonstrate that an Non-Invasive Ventilation (NIV) performs better than a Continuous Positive Airway Pressure (CPAP) in the management of Cardiogenic Pulmonary Edema (CPE) within an Intensive Care Unit (ICU) setting.
Eligibility Criteria
Inclusion Criteria
- Participants suffering from CPE, defined as having the presence of dyspnea, respiratory rate >25 breaths/minute, the use of accessory respiratory muscles, cyanosis, cold sweats, bilateral crackles and/or wheezing on pulmonary auscultation, hypoxaemia, hypertension, and a predominance of bilateral pulmonary infiltrates upon a chest radiography (if available).
- The potential causes of CPE have been understood to be Acute Coronary Syndrome (ACS) with or without a persistent ST-segment elevation, hypertensive emergency, valvulopathy, acute arrhythmia, endocarditis, or decompensation due to a chronic heart failure.
Exclusion Criteria
- The exclusion criteria were: a refused consent, the patient's inability to cooperate, severe encephalopathy (Glasgow Coma Score 0.5 µg/kg/min).
Data sourced from ClinicalTrials.gov (NCT02977572). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.