Phase 4
N=30
Cardiovascular Effects of Adderall in Healthy Adults.
Hemodynamics · Cardiovascular System
Bottom Line
View on ClinicalTrials.gov: NCT02979327 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Systolic Blood Pressure — 116; 116; 126; 115 mmHg
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Adderall capsule (Drug); Placebo capsule (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Mayo Clinic
- Primary completion
- Jul 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Systolic Blood Pressure |
116; 116; 126; 115 | — |
| PRIMARY Diastolic Blood Pressure |
72; 72; 78; 71 | — |
| PRIMARY Mean Arterial Pressure (MAP) |
87; 86; 94; 86 | — |
| PRIMARY Heart Rate |
60; 59; 70; 61 | — |
| SECONDARY Plasma Norepinephrine |
215; 217; 301; 227 | — |
Summary
This study is designed to investigate the cardiovascular response (blood pressure, heart rate, electrocardiographic response and blood vessel reactivity response) to taking Adderall in healthy adults.
Eligibility Criteria
Inclusion Criteria
- Adults 18 years of age and older
- Healthy subjects without known cardiovascular disease, thyroid disease or documented mental health illness
- Subjects who are on no medications
- Subjects with no prior history of regular amphetamine use, and non-prescription stimulants
- Nonsmokers
Exclusion Criteria
- Subjects with known cardiovascular disease, thyroid disease
- Subjects with history of psychotic disorders/mental health illness, including but not limited to anxiety, depression, bipolar disorder; history of substance abuse or dependence
- Subjects currently taking medications
- Prior history of regular amphetamine use, or non-prescription stimulants
- Smokers
- Pregnant subjects
- Known lactose intolerance (due to presence of lactose in the prepared medication)
- Family history of sudden cardiac death
Data sourced from ClinicalTrials.gov (NCT02979327). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.