Phase 2
Completed N=157
Marijuana's Impact on Alcohol Motivation and Consumption
Alcohol Drinking · Marijuana
Source: ClinicalTrials.gov NCT02983773 ↗
Enrolled (actual)
157
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcomePrimary: Alcohol Craving — 2.54; 2.64; 2.65; 2.55 units on a scale
Summary
This laboratory study will employ a repeated measures experimental design to examine the effect of high (7.2% THC) and moderate (3.1% THC) dose of marijuana, relative to placebo, on alcohol craving and on behavioral economic measure of alcohol demand after exposure to alcohol cues, and on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consume. The study will recruit 173 non-treatment seeking heavy episodic alcohol drinkers who smoke marijuana at least twice weekly.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Alcohol Craving |
2.54; 2.64; 2.65; 2.55; 2.64; 2.67 | — |
| SECONDARY Percent of Total Available Alcohol Consumed |
26.61; 29.52; 36.25 | — |
Eligibility Criteria
Inclusion Criteria
- Age 21 to 44
- English-speaking
- marijuana smoking in past month
- report of current heavy episodic (binge) drinking
- in good physical health and weighing 20 tobacco cigarettes per day
- positive pregnancy test
- nursing
- positive urine toxicology screen for drugs other than cannabis
- interest to quit or receive treatment for marijuana or alcohol use
- meeting criteria for a current affective disorder (depression, or mania, panic disorder, and having psychotic symptoms as assessed by the SCID)
Data sourced from ClinicalTrials.gov (NCT02983773). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.