N/A
N=51
Steroid Nasal Irrigation for Flavor Evaluation and Detection Study
Olfactory Disorder
Bottom Line
View on ClinicalTrials.gov: NCT02985515 ↗Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Nov 2022
Primary outcome: Primary: Pre- and Post-intervention Difference in Functional Connectivity Before and After Smell Training. — 5 Regions of interest
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Smell training (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Washington University School of Medicine
- Primary completion
- Nov 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pre- and Post-intervention Difference in Functional Connectivity Before and After Smell Training. |
5 | — |
| SECONDARY Pre- and Post-intervention Difference in Smell Testing Before and After Budesonide Treatment |
19.5; 17.5 | — |
| SECONDARY Subjective Response to Smell Training Intervention |
23.8 | — |
| SECONDARY Comparison of Olfactory Network in Healthy Controls to Study Participants |
13 | — |
| SECONDARY Pre- and Post-intervention Difference in Smell Testing Before and After Smell Training |
19; 18.3 | — |
| SECONDARY Pre and Post Difference in QOD-NS After Smell Training |
7.4 | — |
Summary
The purpose of this research study is to examine the efficacy of a 12-week smell training intervention for participants with olfactory dysfunction following an infection of the upper respiratory tract.
Eligibility Criteria
Inclusion Criteria
- Age between 18 and 70
- Anosmia or hyposmia (UPSIT <34 (male), UPSIT <34 (female); Sniffin' Sticks threshold below 5.5)
Exclusion Criteria
- Inability to understand English
- Current smoker or history of smoking within the past 6 months
- Current nasal polyps
- Exposure to head and or/neck radiation
- Exposure to chemotherapy
Data sourced from ClinicalTrials.gov (NCT02985515). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.