N/A
N=32
Effort of Breathing Guided Ventilator Protocol
Ventilators, Mechanical · Work of Breathing
Bottom Line
View on ClinicalTrials.gov: NCT02989246 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Oct 2021
Primary outcome: Primary: Percentage of Protocol Recommendations Which Are Accepted by the Clinical Provider — 76 percentage adherant
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Ventilator protocol (Other); Esophageal Catheter (Device)
- Age
- Pediatric, Adult · 0+ yrs
- Sex
- All
- Sponsor
- Children's Hospital Los Angeles
- Primary completion
- Oct 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Protocol Recommendations Which Are Accepted by the Clinical Provider |
76 | — |
Summary
This pilot study tests the feasibility of using a computerized ventilator management protocol seeking to encourage lung protective ventilation during the acute phase of ventilation, and esophageal manometry based titration of ventilator settings during the weaning phase of ventilation, for children with acute respiratory failure. The investigators hypothesize that such an approach will reduce time on mechanical ventilation, largely by preserving diaphragm muscle function.
Eligibility Criteria
Inclusion Criteria
- Intubated and mechanically ventilated patients in the Children's Hospital Los Angeles Pediatric ICU
- Anticipated length of intubation > 48 hours.
- The primary attending physician approves use of the protocol on the patient.
Exclusion Criteria
- Corrected gestational age less than 37 weeks
- Contraindications to nasoesophageal catheter placement (nasopharyngeal or esophageal abnormalities) or Respiratory Inductance Plethysmography bands (abdominal wall defects such as omphalocele).
- Significant lower airway obstruction (asthma or bronchiolitis), confirmed by ventilator spirometry
Data sourced from ClinicalTrials.gov (NCT02989246). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.