N/A N=864,080 Randomized Health Services Research

CT DOSE Collaboratory

Ionizing Radiation Exposure · Quality Improvement

Bottom Line

View on ClinicalTrials.gov: NCT03000751 ↗

Enrolled (actual)

864,080

Serious AEs

—

Results posted

Mar 2024

Primary outcome: Primary: Change in Mean Effective Dose (ED) — -0.13; -0.81; -0.14; -0.26 Millisieverts (mSv)

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Simple Audit Report (Other); Multi-Component Intervention (Other); In-Person Meeting (Other)
Age: Pediatric, Adult, Older Adult
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Dec 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Mean Effective Dose (ED)	-0.13; -0.81; -0.14; -0.26; -0.88; -2.04	—
PRIMARY Percentage of CT Scans With an Effective Dose Above Benchmark	24.7; 24.7; 22.2; 26; 25.5; 24.9	—
SECONDARY Mean Dose Length Product	—	—
SECONDARY Proportion of CT Scans With a Dose Length Product Above Benchmark	—	—
SECONDARY Change in Mean Volume Computed Tomography Dose Index (CTDIvol)	0.09; 0.03; 0.04; -0.11; -0.05; -0.42	—
SECONDARY Percentage of CT Scans With a CTDIvol Above Benchmark	24.5; 24.9; 24.1; 26; 25.8; 24.1	—
SECONDARY Change in Mean Organ Doses: Brain Dose for Head CT; Lung Dose For Chest CT; Colon and Liver Dose for Abdomen CT	-6.0; -12.2; -2.1; -3.7; -16.0; -30.1	—

Summary

This is a pragmatic stepped-wedge cluster randomized controlled trial to explore variation in doses used for diagnostic CT by pooling radiation dose data across diverse healthcare delivery systems. To compare different strategies for lowering and optimizing dose and identify the barriers and facilitators to implementing successful dose optimization strategies and standardizing practice.

Eligibility Criteria

Inclusion Criteria

Diagnostic CT scans of the head, chest, and/or abdomen/pelvis performed within the study period

Exclusion Criteria

non-diagnostic scans that are not of the head, chest, and/or abdomen/pelvis

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03000751). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.