Study of Oral Lasmiditan in Participants With Normal and Impaired Renal Function

Inclusion Criteria

• Motivated participant and absence of intellectual problems likely to limit the validity of consent to participate in the study or the compliance with protocol requirements; ability to cooperate adequately; ability to understand and observe the instructions of the physician or designee
• Male or female participant
• A female participant if of childbearing potential - must be willing to use accepted contraceptive regimens from at least 28 days prior to the drug administration, during the study and for at least 60 days after the dose.
• A male participant with sexual partners who are of child bearing potential must be willing to use accepted contraceptive regimens.
• A male participant agrees to refrain from sperm donation from drug administration until 3 months after the drug administration
• Participant aged of at least 18 years
• Participant with a body mass index (BMI) ≥18.50 kilogram per meter squared (kg/m²) and 3 units of alcohol per day, intake of excessive alcohol, acute or chronic)
• Use of any enzyme-modifying drugs, including strong inhibitors of cytochrome P450 (CYP) enzymes (such as cimetidine, fluoxetine, quinidine, erythromycin, ciprofloxacin, fluconazole, ketoconazole, diltiazem and HIV antivirals) and strong inducers of CYP enzymes (such as barbiturates, carbamazepine, glucocorticoids, phenytoin, rifampin and St John's Wort), in the previous 28 days before Day 1 of this study
• Females who are pregnant according to a positive pregnancy test
• Participants who took lasmiditan in the previous 28 days before Day 1 of this study
• Participants who took an Investigational Product (in another clinical trial) in the previous 28 days before Day 1 of this study
• Participants who have already participated in this clinical study
• Participants who donated 50 mL or more of blood in the previous 28 days before Day 1 of this study
• Donation of 500 mL or more of blood (Canadian Blood Services, Hema-Quebec, clinical studies, etc.) in the previous 56 days before Day 1 of this study

Participants with Normal Renal Function:

• Seated pulse rate less than or equal 40 Beats per Minute (bpm) or more than - Seated blood pressure below 90/60 millimeters of mercury (mmHg) or higher than 140/90 mmHg at screening
• Presence of significant gastrointestinal, liver, or kidney disease, or any other conditions known to interfere with the absorption, distribution, metabolism, or excretion of drugs or known to potentiate or predispose to undesired effects
• History of significant gastrointestinal, liver or kidney disease that may affect drug bioavailability, including but not limited to cholecystectomy
• Presence of significant cardiovascular, pulmonary, hematologic, neurological, psychiatric, endocrine, immunologic or dermatologic disease
• Presence of out-of-range cardiac interval (PR 220 msec, QRS 119 msec and correct QT interval (QTc) > 450 msec for males and > 460 msec for females) on the screening ECG or other clinically significant ECG abnormalities
• Positive screening of alcohol and/or drugs of abuse
• Any clinically significant illness in the previous 28 days before Day 1 of this study

Renal Impaired Participants:

• Seated pulse rate less than 50 bpm or more than 110 bpm at screening
• Seated blood pressure below 90/50 mmHg or higher than 180/110 mmHg at screening
• Currently undergoing any method of dialysis
• History of renal transplant
• History or presence, in the opinion of the Investigator, of significant clinically unstable respiratory, cardiovascular, pulmonary, hepatic, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, or psychiatric disease,
• Have poorly controlled Type 1 or Type 2 diabetes as defined by Hemoglobin A1c >10%
• Require immunosuppressive medications for treatment of immune-mediated renal disease or kidney transplant recipients
• Evidence of renal carcinoma present at the time of screening
• Have relevant clinical laboratory abnormalities, including any