N/A N=35 Randomized Single-blind Prevention

A Novel Cognitive Reappraisal Intervention for Suicide Prevention

Suicide Prevention

Bottom Line

View on ClinicalTrials.gov: NCT03026127 ↗

Enrolled (actual)

Serious AEs

23.4%

Results posted

Oct 2025

Primary outcome: Primary: Change in Late Positive Potential, as Measured by the Electroencephalagram (EEG), Autobiographical Affective Regulation Task (AART), and a Standard Picture-based Emotion Regulation Task. (Only for the R33) — 5.61; 4.38; 1.51; 0.48 μVoltage

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Cognitive Reappraisal Intervention for Suicide Prevention (Behavioral); Supportive Therapy (Behavioral)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: Weill Medical College of Cornell University
Primary completion: Oct 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Late Positive Potential, as Measured by the Electroencephalagram (EEG), Autobiographical Affective Regulation Task (AART), and a Standard Picture-based Emotion Regulation Task. (Only for the R33)	5.61; 4.38; 1.51; 0.48; 2.09; 0.78	—
PRIMARY Changes in Electrocortical Measures (i.e., Late Positive Potential, LPP) (Only for the R61)	4.99; 3.10	—

Summary

The goal of this trial is to refine and test a novel emotion-regulation based psychosocial intervention designed to reduce suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).

Eligibility Criteria

Inclusion Criteria

50 years and older
Diagnosis (based on SCID-5 Clinical Trials Version to assess DSM-5 diagnoses): Any DSM-5 depression or anxiety diagnosis, including major depressive disorder, bipolar depression, depressive disorder Not Elsewhere Classified, anxiety disorder Not Elsewhere Classified, adjustment disorder with anxiety and depressed mood (but without any of the diagnoses shown under Exclusion Criteria)
Recent hospitalization for suicidal ideation or suicide attempt. At hospital admission, Columbia Suicide Severity Rating Scale greater or equal to 3, "Active Suicidal Ideation with any methods or a suicide attempt."
Patients with any degree of suicidal ideation at discharge (Columbia Suicide Severity Rating greater or equal to 0) will be included.
Patients who are on psychotropics and on after-care community psychotherapy will also be included.

Exclusion Criteria

History or current diagnosis of Psychotic Disorders; Current Diagnosis of Bipolar I or Bipolar II, with current episode hypomanic, manic or mixed; Diagnosis of Dementia.
Cognitive Impairment: Mini Mental State Exam (MMSE) < 24.
Acute or severe medical illness (i.e. delirium; decompensated cardiac, liver, or kidney failure; major surgery; stroke or myocardial infarction during the three months prior to entry.
Aphasia, sensory problems, and/or inability to speak English.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03026127). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.