Phase 2 N=50 Randomized Double-blind Prevention

A Double-blind Randomized Placebo Controlled Clinical Trial Evaluating Effect of Chlorhexidine Gluconate 2% Cloth vs Placebo Cloth Baths on the Incidence of Central Line-Associated Blood Stream Infections in Outpatient Hematopoietic Stem Cell Transplant Patients

Stem Cell Transplant Complications

Bottom Line

View on ClinicalTrials.gov: NCT03030989 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2020

Primary outcome: Primary: Number of Participants With Primary Blood Stream Infections — 1; 2 Participants

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Chlorhexidine Gluconate 2% Wipe (Drug); Placebo Wipe (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Chicago
Primary completion: Jan 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Primary Blood Stream Infections	1; 2	—
PRIMARY Number of Participants With Clinical (Culture-negative) Sepsis	0; 0	—

Summary

This study evaluates the use of 2% CHG washcloths in an outpatient setting for adults after hematopoietic stem cell transplant in prevention of central line associated blood stream infections. Half of the participants will use 2% CHG washcloths and other half will use placebo washcloths.

Eligibility Criteria

Inclusion Criteria

Admitted to the University of Chicago Hematopoietic Stem Cell Transplant Unit for transplant
Age 18 and up

Exclusion Criteria

Experienced an allergy or rash related to use of chlorhexidine washcloths or other chlorhexidine products
Extensive open wounds

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Data sourced from ClinicalTrials.gov (NCT03030989). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.