N/A N=49 Randomized Triple-blind Basic Science

Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory

Healthy Adults

Bottom Line

View on ClinicalTrials.gov: NCT03032796 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2025

Primary outcome: Primary: mCPT (Derived From Test of Variables of Attention (T.O.V.A.)) — 72.5; 52.2 milliseconds

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Body-Brain Trainer (Behavioral); Body Trainer (Behavioral); Brain Trainer (Behavioral); Expectancy Matched Control (Behavioral)
Age: Adult, Older Adult · 55+ yrs
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Mar 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY mCPT (Derived From Test of Variables of Attention (T.O.V.A.))	72.5; 52.2	—
SECONDARY Delayed Recognition Working Memory Task: Response Time Variability Prior to and 9-weeks After Baseline	29.7; 24.1	—

Summary

The primary goal of this project is to evidence potential synergistic benefits on cognitive control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a complimentary fashion. Healthy adults will be recruited for a longitudinal experiment and randomly assigned to one of four study groups to mechanistically tease apart the possible presence of any synergistic effects on cognitive abilities through the combination of cognitive & physical challenges.

Eligibility Criteria

Inclusion Criteria

Can walk briskly for at least 15 minutes continuously without stopping
Can stand up from a chair without using your hands
Available to come 3x/week to our UCSF Mission Bay laboratory for 8 weeks
Willing and able to undergo MRI, EEG procedures
English fluency

Exclusion Criteria

cardiac problems
bypass surgery
pacemaker or heart valve replacement
stroke
respiratory conditions
head trauma with loss of consciousness for less than a few minutes
severe head trauma with loss of consciousness for more than a few minutes
high/low blood pressure
kidney failure
electroconvulsive therapy (ECT)
seizures
implanted electrodes
cancer/chemotherapy/radiation
diabetes
irritable bowel syndrome
back problems
claustrophobia
Having been diagnosed with a psychiatric or neurological disorder
Use of an assistive device (e.g., cane or walker) at any time to assist with ambulation
Joint problems causing significant pain upon movement
Heart Disease or Cardiovascular Disease
Respiratory Disease (Lung Disease)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03032796). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.