N/A
Completed N=49
Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory
Healthy Adults
Source: ClinicalTrials.gov NCT03032796 ↗
Enrolled (actual)
49
Serious AEs
0.0%
Results posted
Sep 2025
Primary outcomePrimary: mCPT (Derived From Test of Variables of Attention (T.O.V.A.)) — 72.5; 52.2 milliseconds
Summary
The primary goal of this project is to evidence potential synergistic benefits on cognitive control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a complimentary fashion. Healthy adults will be recruited for a longitudinal experiment and randomly assigned to one of four study groups to mechanistically tease apart the possible presence of any synergistic effects on cognitive abilities through the combination of cognitive & physical challenges.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY mCPT (Derived From Test of Variables of Attention (T.O.V.A.)) |
72.5; 52.2 | — |
| SECONDARY Delayed Recognition Working Memory Task: Response Time Variability Prior to and 9-weeks After Baseline |
29.7; 24.1 | — |
Eligibility Criteria
Inclusion Criteria
- Can walk briskly for at least 15 minutes continuously without stopping
- Can stand up from a chair without using your hands
- Available to come 3x/week to our UCSF Mission Bay laboratory for 8 weeks
- Willing and able to undergo MRI, EEG procedures
- English fluency
Exclusion Criteria
- cardiac problems
- bypass surgery
- pacemaker or heart valve replacement
- stroke
- respiratory conditions
- head trauma with loss of consciousness for less than a few minutes
- severe head trauma with loss of consciousness for more than a few minutes
- high/low blood pressure
- kidney failure
- electroconvulsive therapy (ECT)
- seizures
- implanted electrodes
- cancer/chemotherapy/radiation
- diabetes
- irritable bowel syndrome
- back problems
- claustrophobia
- Having been diagnosed with a psychiatric or neurological disorder
- Use of an assistive device (e.g., cane or walker) at any time to assist with ambulation
- Joint problems causing significant pain upon movement
- Heart Disease or Cardiovascular Disease
- Respiratory Disease (Lung Disease)
Data sourced from ClinicalTrials.gov (NCT03032796). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.