N/A
N=360
Effects of Vitamin D on Moderate to Severe Periodontitis
Chronic Peritonitis
Bottom Line
View on ClinicalTrials.gov: NCT03044886 ↗Enrolled (actual)
360
Serious AEs
0.0%
Results posted
Feb 2019
Primary outcome: Primary: Attachment Loss (AL) — 4.7; 4.8; 4.8 mm — p=0.576
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- vitamin D (Dietary_supplement)
- Age
- Adult, Older Adult · 30+ yrs
- Sex
- All
- Sponsor
- Beijing Chao Yang Hospital
- Primary completion
- Dec 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Attachment Loss (AL) |
3.4; 3.3; 3.3 | 0.042 sig |
| PRIMARY Attachment Loss (AL) |
3.4; 3.3; 3.3 | 0.042 sig |
| PRIMARY Attachment Loss (AL) |
3.4; 3.3; 3.3 | 0.042 sig |
| SECONDARY Probing Depth (PD) |
2.4; 2.5; 2.5 | 0.048 sig |
| SECONDARY Probing Depth (PD) |
2.4; 2.5; 2.5 | 0.048 sig |
| SECONDARY Probing Depth (PD) |
2.4; 2.5; 2.5 | 0.048 sig |
| SECONDARY Alveolar Crest Height (ACH) |
7.7; 7.7; 7.7 | <0.05 sig |
| SECONDARY Alveolar Crest Height (ACH) |
7.7; 7.7; 7.7 | <0.05 sig |
| SECONDARY Alveolar Crest Height (ACH) |
7.7; 7.7; 7.7 | <0.05 sig |
| SECONDARY Bleeding Index (BI) |
0.9; 1.2; 1.1 | 0.075 |
| SECONDARY Bleeding Index (BI) |
0.9; 1.2; 1.1 | 0.075 |
| SECONDARY Bleeding Index (BI) |
0.9; 1.2; 1.1 | 0.075 |
Summary
The object of the study was to evaluate the direct effect of high dose vitamin D supplementation on chronic periodontitis, and suggest the recommended dose for clinic use.
Eligibility Criteria
Inclusion Criteria
- Age from 30 years old to 70 years old
- More than 20 teeth remaining in the mouth
- Clinical diagnosis of moderate to severe periodontitis
- Not receiving periodontal treatment within 6 months
- Not taking antibiotic drugs within 3 months.
Exclusion Criteria
- Diabetes, thyroid and parathyroid endocrine associated diseases
- Severe systemic diseases, such as cancer
- Taking vitamin D and / or calcium drugs during observation
- Taking aspirin, non-steroidal anti-inflammatory drugs, and steroids
- Pregnant or prepare to pregnant within one year
- Have been suffering from hypercalcemia, malabsorption syndrome.
Data sourced from ClinicalTrials.gov (NCT03044886). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.