N/A Completed N=35 Randomized Triple-blind Treatment

Light Therapy as Treatment for Fatigue in Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Source: ClinicalTrials.gov NCT03060759 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2020

Primary outcomePrimary: Change in Average Fatigue Severity Scale (FSS) Score — 45.824; 46.714 score on a scale

Summary

This prospective study will randomize 1:1 people living with multiple sclerosis-associated fatigue to one of two spectra of light therapy. Each participant will be asked to use the light box twice daily at home or at the workplace at preset hours during the day for a total of four weeks. Participants will be asked to record their fatigue on standard measurement scales before, during, and after the use of the light therapy box. The investigators anticipate a reduction in self-reported fatigue following the use of the light box therapy of a particular spectrum of light among people living with multiple sclerosis.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Average Fatigue Severity Scale (FSS) Score	45.824; 46.714	—

Eligibility Criteria

Inclusion Criteria

Relapsing remitting Multiple Sclerosis based on the McDonald Criteria (2010)
Over 18 years old
Presence of fatigue defined as FSS over 36

Exclusion Criteria

A change in an anti-depressant up to 4 weeks prior to study screening
A change in fatigue medication regime or MS disease modifying therapy up to 4 weeks prior to study screening
Shift work
Use of photosensitizing medication
Presence of eye trauma or acute optic neuritis within the preceding 3 months
History of traumatic brain injury
Probable (untreated) sleep apnea based on Berlin questionnaire
Significant anemia
History of mania
MS relapse in the preceding four weeks
Current pregnancy
Known light sensitivity
Other complicating illness preventing study completion.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03060759). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.