Phase 3
Completed N=444
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
Source: ClinicalTrials.gov NCT03061812 ↗Enrolled (actual)
444
Serious AEs
56.3%
Results posted
Feb 2021
Primary outcomePrimary: Overall Survival (OS) — 8.57; 6.34 months — p=0.0051
◆ Published Evidence
Highly cited
119citations · ~15 / year
Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer.
Summary
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy.
Linked Publications
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Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overall Survival (OS) |
8.57; 6.34 | 0.0051 sig |
| SECONDARY Progression Free Survival (PFS) |
4.27; 3.02 | < 0.0001 sig |
| SECONDARY Change From Baseline of the Physical Functioning Scale Score in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15-Palliative Care (EORTC QLQ-C15-PAL) at Week 7 |
-7.16; -7.66 | — |
| SECONDARY Objective Response Rate (ORR) |
20.9; 14.6 | 0.3352 |
| SECONDARY Clinical Benefit Rate (CBR) |
43.4; 35.9 | 0.0358 sig |
| SECONDARY Duration of Objective Response (DOR) |
4.86; 3.52 | — |
Eligibility Criteria
Inclusion Criteria
- Participant must have histologically or cytologically confirmed advanced or metastatic Small Cell Lung Cancer (SCLC) with documented first disease progression during or following front-line platinum-based systemic regimen
- Tumor must have high Delta-like protein 3 (DLL3) expression defined as having ≥ 75% tumor cells staining positive according to the VENTANA DLL3 (SP347) IHC Assay.
- Participant must have measurable disease, as defined per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
- Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Participant must have recovery to Grade 0 or 1 of any clinically significant toxicity (excluding alopecia) prior to initiation of study drug administration.
Exclusion Criteria
- Participant has a documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms consistent with New York Heart Association Class (NYHA) III - IV within 6 months prior to their first dose of study drug.
- Participant has known leptomeningeal metastases.
- Participant has received more than one prior systemic therapy regimen for SCLC.
- Participant had a serious infection within 2 weeks prior to randomization, including any Grade 3 or higher viral, bacterial, or fungal infection.
- Participant has a history of active malignancies other than SCLC within the past 2 years prior to study entry, with the exception of in situ cancer which was curatively treated.
- Participant had prior exposure to topotecan, irinotecan or any other topoisomerase I inhibitors.
Data sourced from ClinicalTrials.gov (NCT03061812) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.