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Phase 4 Completed N=161 Randomized Quadruple-blind Treatment

Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval

Infertility, Female · Pain, Postoperative
Source: ClinicalTrials.gov NCT03073980 ↗
Enrolled (actual)
161
Serious AEs
0.0%
Results posted
Apr 2022
Primary outcomePrimary: Post-operative Pain Score Difference 10 Mins From Pre-operative — 1.3; 1.3; 1.8 score on a scale
◆ Published Evidence
Emerging
6citations · ~2 / year
Assessing efficacy of intravenous acetaminophen for perioperative pain control for oocyte retrieval: a randomized, double-blind, placebo-controlled trial.
Fertility and sterility · 2022 · Open access · Likely link

Summary

In this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge from the hospital. We will compare three types of pre-operative medications: intravenous (IV) acetaminophen, oral (PO) acetaminophen, and placebo (no medication), which is the current typical care.

Linked Publications

  • Assessing efficacy of intravenous acetaminophen for perioperative pain control for oocyte retrieval: a randomized, double-blind, placebo-controlled trial.
    Fertility and sterility · 2022 · 6 citations · Open access · Likely link

Outcome Measures

OutcomeResultp-value
PRIMARY
Post-operative Pain Score Difference 10 Mins From Pre-operative
1.3; 1.3; 1.8
PRIMARY
Time to Discharge From the Post-operative Recovery Room
60.1; 58.8; 57.6
SECONDARY
Procedure Length
13.5; 13.7; 14.1
SECONDARY
Postoperative Nausea and Vomiting
3; 4; 2
SECONDARY
Oocyte Yield
12.6; 13.4; 11.4
SECONDARY
Rescue Medication Required
4; 10; 8

Eligibility Criteria

Inclusion Criteria

[ ] Patient is 18 years or over, undergoing oocyte retrieval. [ ] Patient is English-speaking.

Exclusion Criteria

[ ] Allergy/hypersensitivity to acetaminophen or opiates. [ ] Any history of liver disease, history of alcohol depending, or renal impairment as reported in the electronic health record.

[ ] Any history chronic opiate use or chronic pain disorder reported in the electronic health record.

[ ] Weight less than 50kg as reported in the medical record.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03073980) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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