N/A Completed N=100 Randomized Diagnostic

Evaluating Effectiveness of Powered Drill Bone Marrow Biopsy

Multiple Myeloma

Source: ClinicalTrials.gov NCT03078452 ↗

Enrolled (actual)

100

Serious AEs

0.0%

Results posted

Sep 2025

Primary outcomePrimary: Bone Marrow Core Biopsy Length (in mm) and Artifacts Assessed by the Pathologist — 14; 9.5 Millimeters

Summary

Since the introduction of the Jamshidi needle in 1971, new advances in bone marrow sampling have not been seen. In 2007, a new battery-powered bone marrow biopsy system was developed. This technology, using a battery-powered drill to operate the needle accessing the posterior iliac bone, was approved by the Food and Drug Administration (FDA) and is currently commercially available. Few randomized controlled trials (RCTs) have compared the use of the battery-powered bone marrow biopsy system to the Jamshidi needle (the traditional manual) method of bone marrow sampling. This research study is designed to evaluate the effectiveness of the Jamshidi needle compared to the battery-powered bone marrow biopsy system. 100 participants will be enrolled in this study at Emory University.

Outcome Measures

Outcome	Result	p-value
PRIMARY Bone Marrow Core Biopsy Length (in mm) and Artifacts Assessed by the Pathologist	14; 9.5	—
SECONDARY Intensity of Pain Measured Using Visual Analogue Scale (VAS) Pain Questionnaire	.66; .84; 1.62; 1.62; .89; .63	—
SECONDARY Time Taken by the Procedure Measured in Seconds Using a Stopwatch	7; 10.5	—

Eligibility Criteria

Inclusion Criteria

All patients with existing plasma cell disorders and no history of psychiatric disorders who can receive conscious sedation are eligible to participate in the trial

Exclusion Criteria

Pregnant women are excluded from participating in this study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03078452). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.