N/A
Completed N=1,502
Functional Genetic Variants Affecting Tacrolimus Trough Levels and Side Effects in Chinese Renal Transplantation.
Transplantation
Source: ClinicalTrials.gov NCT03083769 ↗
Enrolled (actual)
1,502
Serious AEs
20.2%
Results posted
Nov 2019
Primary outcomePrimary: Number of Participants With Acute Rejection — 256; 37 participants
Summary
The purpose of this study is to determine whether functional genetic variants can affect tacrolimus dose corrected trough levels and associate with the side effects in Chinese renal transplant recipients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Acute Rejection |
256; 37 | — |
| PRIMARY Number of Participants With Tacrolimus-related Nephrotoxicities |
26; 2 | — |
| PRIMARY Number of Participants With Tacrolimus-related Neurotoxicities |
10; 1 | — |
Eligibility Criteria
Inclusion Criteria
Subject has been conducted kidney transplantation. Subject has used tacrolimus as immunosuppressant.
Exclusion Criteria
Simultaneous liver-kidney transplantation. Patients with age less than 18 years old. Tacrolimus blood concentration monitoring less than 3 times. Failed to extract DNA.
Data sourced from ClinicalTrials.gov (NCT03083769). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.