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N/A Completed N=247 Randomized Single-blind Supportive Care

Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

Lung Cancer
Source: ClinicalTrials.gov NCT03089125 ↗
Enrolled (actual)
247
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcomePrimary: Modified Medical Research Council Dyspnea Scale (mMRCDS) — 1.88; 1.55 units on a scale — p=0.038

Summary

This research study is evaluating a behavioral intervention designed to help people with advanced lung cancer manage dyspnea (i.e., breathlessness or shortness-of-breath).

Outcome Measures

OutcomeResultp-value
PRIMARY
Modified Medical Research Council Dyspnea Scale (mMRCDS)		 -0.89; -0.95 0.710
PRIMARY
Cancer Dyspnoea Scale (CDS)		 -2.63; -2.26 0.677
SECONDARY
Functional Assessment of Cancer Therapy - Lung (FACT-L)		 4.86; 2.91 0.330
SECONDARY
Hospital Anxiety and Depression Scale (HADS) - Anxiety Subscale		 -1.00; -0.28 0.098
SECONDARY
Hospital Anxiety and Depression Scale (HADS) - Depression Subscale		 -0.18; -0.10 0.845
SECONDARY
Activity Level (Self-report: Godin-Shephard Leisure Time Physical Activity Questionnaire)		 0.54; 1.28 0.837
SECONDARY
Activity Level (Objective Measure: Actigraphy)		 45.80; 47.42 0.431

Eligibility Criteria

Inclusion Criteria

  • A diagnosis of either NSCLC, SCLC, or mesothelioma, not being treated with curative intent
  • Self-reported shortness of breath (a score of 2 or greater on the Modified Medical Research Council Dyspnea Scale)
  • Eastern Cooperative Oncology Group (ECOG) Performance Status from 0 (asymptomatic) to 2 (symptomatic and in bed 18 years

Exclusion Criteria

  • Cognitive or psychiatric conditions prohibiting study consent or participation.
  • A treating clinician who reports that the patient is inappropriate for the study
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03089125). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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