Phase 4
Completed N=86
Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)
Knee Arthropathy
Source: ClinicalTrials.gov NCT03094663 ↗
Enrolled (actual)
86
Serious AEs
0.0%
Results posted
Jan 2024
Primary outcomePrimary: Numeric Rating Scale (NRS) Pain Scores — 5.0; 1.7 score on a scale
◆ Published Evidence
Highly cited
132citations · ~19 / year
Addition of Infiltration Between the Popliteal Artery and the Capsule of the Posterior Knee and Adductor Canal Block to Periarticular Injection Enhances Postoperative Pain Control in Total Knee Arthroplasty: A Randomized Controlled Trial.
Summary
A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK) versus the Periarticular Injection (PAI) - in patients undergoing total knee arthroplasty. Primary outcome is NRS pain scores with ambulation on postoperative day one (24 hours post-block administration).
Linked Publications
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Addition of Infiltration Between the Popliteal Artery and the Capsule of the Posterior Knee and Adductor Canal Block to Periarticular Injection Enhances Postoperative Pain Control in Total Knee Arthroplasty: A Randomized Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Numeric Rating Scale (NRS) Pain Scores |
5.0; 1.7 | — |
| SECONDARY Opioid Consumption |
69.1; 40.6 | — |
| SECONDARY Numeric Rating Scale (NRS) Pain Scores at Rest and With Movement |
3.4; 1.2 | — |
| SECONDARY Ambulation Distance During Physical Therapy |
23.2; 25.7; 81.1; 87.7; 112; 116.7 | — |
| SECONDARY Level of Patient Satisfaction With Postoperative Pain Management |
8.8; 9.5 | — |
| SECONDARY Pain Outcomes |
6.9; 5.6 | — |
| SECONDARY Hospital Length of Stay |
2991; 3081 | — |
| SECONDARY Opioid Related Symptom Distress Scale (ORSDS) |
0.4; 0.3; 0.5; 0.4 | — |
| SECONDARY Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS Jr) |
54; 52; 73; 77 | — |
Eligibility Criteria
Inclusion Criteria
- Patients with osteoarthritis scheduled for a primary either partial or total knee arthroplasty with a participating surgeon
- Age 18 to 80 years
- Planned use of regional anesthesia
- Ability to follow study protocol
- English speaking (secondary outcomes include questionnaires validated in English only)
- Patients of participating surgeons
Exclusion Criteria
- Hepatic or renal insufficiency
- Younger than 18 years old and older than 80
- Patients undergoing general anesthesia
- Allergy or intolerance to one of the study medications
- BMI > 40
- Diabetes
- ASA of IV
- Chronic gabapentin/pregabalin use (regular use for longer than 3 months)
- Chronic opioid use (taking opioids for longer than 3 months, or daily oral morphine equivalent of >5mg/day for one month)
- Patients with severe valgus deformity and flexion contracture
Data sourced from ClinicalTrials.gov (NCT03094663) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.