Early Phase 1 Completed N=44 Randomized Triple-blind Treatment

Comparison of the Cosmetic Effects of Bakuchiol and Retinol

Wrinkle · photoaging

Source: ClinicalTrials.gov NCT03112863 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Nov 2021

Primary outcomePrimary: Change in Wrinkle Appearance — 19.0; 23.2 percentage of reduced fine wrinkles

Summary

Subjects will be assigned to a retinoid cream or bakuchiol to compare the cosmetic effects. This will take place over a 12 week period.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Wrinkle Appearance	19.0; 23.2	—
PRIMARY Percentage of Participants With Change in Appearance of Skin Pigmentation	59; 44	—
SECONDARY Number of Reports of Stinging, Burning, Itching	0; 0	—
SECONDARY Number of Reports of Facial Erythema Assessment	0; 0	—

Eligibility Criteria

Inclusion Criteria

Individuals aged 30-55

Exclusion Criteria

Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Pregnant or breast feeding women
Prisoners
Those with acne, eczema, seborrheic dermatitis, rosacea or polycystic ovarian syndrome
Those who have used isotretinoin in the last 6 months
Those who have used products containing salicylic acid, beta hydroxyl acids or vitamins A, C, or E in the last 14 days
Those who have used topical antibiotics or topical retinoids in the last 30 days
Those who are currently smoking or have smoked within the past 3 years.
Those who have had a recent surgical or cosmetic procedure in the last 3 months that can affect facial wrinkles or facial hyperpigmentation, such as botulinum toxin injections, chemical peels, laser based therapies to the face, or face lift surgeries

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03112863). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.