N/A
N=42
Effectiveness of Three Different Mouthrinses in Dental Plaque Control and Early Wound Healing
Periodontitis · Wound Healing
Bottom Line
View on ClinicalTrials.gov: NCT03119831 ↗Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Jul 2017
Primary outcome: Primary: Assessment of Periodontal Soft Tissue Healing Progress Between Baseline (Immediately After Surgery), 7 and 14 Days Postoperatively (Evaluated by Early Wound Healing Index - EHI) — 3; 3; 2; 2 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Alcohol-based Chlorhexidine Gluconate 0.12% (Drug); Alcohol-free Chlorhexidine Gluconate 0.12% (Drug); C31G (Drug)
- Age
- Adult, Older Adult · 34+ yrs
- Sex
- All
- Sponsor
- National and Kapodistrian University of Athens
- Primary completion
- Jul 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Assessment of Periodontal Soft Tissue Healing Progress Between Baseline (Immediately After Surgery), 7 and 14 Days Postoperatively (Evaluated by Early Wound Healing Index - EHI) |
3; 3; 2; 2; 3; 1 | — |
| SECONDARY Plaque Index (PI) |
2; 2; 1 | — |
| SECONDARY Plaque Area Index (PA%) |
22.8; 20.6; 11.2; 32.5; 14.9; 11.2 | — |
Summary
Aim: This study compared the effectiveness of three different mouthrinses (alcohol and non-alcohol chlorhexidine, alkyl dimethyl glycine / alkyl dimethyl amine oxide - C31G) in plaque control and early wound healing, postoperatively.
Materials and Methods: In this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to two weeks rinsing after periodontal surgery with C31G (group A), alcohol-free chlorhexidine 0.12% (group B) or alcohol-based chlorhexidine 0.12% (group C). At weeks 1 and 2, plaque and early wound healing indices were recorded. At day 14, total bacterial counts were estimated utilizing real - time qPCR. Statistics included linear and generalized linear mixed models.
Eligibility Criteria
Inclusion Criteria
- Patients in need of periodontal pocket elimination / reduction or surgical crown lengthening with or without osseous surgery in one of the following regions: #13-15 or #23-25 or #33-35 or #43-45.
- In cases of pocket elimination / reduction, at least two teeth with ≥ 1 residual periodontal pocket ≥ 5mm and bleeding on probing was mandatory.
- Width of keratinized tissues ≥ 2mm around teeth included in the operated area.
- Cause - related therapy should be completed ≥ 6 weeks before surgical procedure.
- Plaque Index (O'Leary et al. 1972) 7%).
- Smoking > 20 cigarettes/day.
- Systemic antimicrobial therapy the last 3 months before the surgical procedure.
- Steroidal or/and non - steroidal anti-inflammatory drug therapy the last 15 days.
- Immunodeficiency or immunosuppressive drug therapy.
- History or current chemotherapy or/and radiation therapy.
- Oral bisphosphonates intake > 3 years or intravenous bisphosphonates therapy.
- Pregnancy or/and breastfeeding.
- Need for osseous graft and/or membrane or any other regenerative material application.
- Furcation involvement of first maxillary premolars and furcation involvement > class I at the mesial entrance of first maxillary molars.
- Missing teeth, fixed partial dentures, removable dentures or orthodontic brackets in the candidate regions for periodontal surgery.
Data sourced from ClinicalTrials.gov (NCT03119831). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.