Phase 4 N=24 Randomized Double-blind Treatment

Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine

Anesthesia, Local

Bottom Line

View on ClinicalTrials.gov: NCT03127943 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2019

Primary outcome: Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 100; 106 minutes

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Lidocaine (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of North Carolina, Chapel Hill
Primary completion: Apr 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Time to Pulpal Response After Mandibular Molar Anesthesia	100; 106	—
PRIMARY Mean Time to Pulpal Response After Mandibular Canine Anesthesia	81.3; 97.5	—

Summary

Assess the clinical impact of Buffered 1% lidocaine with epinephrine as compared to the Non-buffered 1% lidocaine with epinephrine in dental and oral surgical procedures.

Eligibility Criteria

Inclusion Criteria

Age 18-30 years American Society Anesthesiologists I,II

Exclusion Criteria

Allergy to lidocaine class of anesthetic drugs Local anesthetic drug use in past week Current symptoms in teeth or oral mucosa

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03127943). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.