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Phase 3 N=94 Randomized Single-blind Treatment

Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty

Arthropathy of Knee

Enrolled (actual)
94
Serious AEs
0.0%
Results posted
Jan 2019
Primary outcome: Primary: Mean Distance Ambulated at 24 Hours Post Operatively — 70.2; 48.44 feet

Study Design & Population

Study type
Interventional
Phase
Phase 3
Interventions
Adductor Canal Nerve Block (Procedure); Femoral Nerve Block (Drug)
Age
Adult, Older Adult · 19+ yrs
Sex
All
Sponsor
University of Alabama at Birmingham
Primary completion
Oct 2017

Outcome Measures

OutcomeResultp-value
PRIMARY
Mean Distance Ambulated at 24 Hours Post Operatively
70.2; 48.44
PRIMARY
Mean Distance Ambulated at 48 Hours Post Operatively
129.02; 106.38
SECONDARY
Mean Pain Scores Immediately Preoperatively
3.07; 3.38
SECONDARY
Mean Opioid Consumption as Measured by Oral Morphine Milligram Equivalents
23; 22.33
SECONDARY
Patient Satisfaction at 48 Hours Post Operatively
8.71; 9.24
SECONDARY
Mean Hours to Discharge
89.66; 83.78
SECONDARY
Mean Pain Scores in PACU
3.91; 2.98
SECONDARY
Mean Pain Scores at 24 Hours
4.18; 4
SECONDARY
Mean Pain Scores 48 Hours Postoperatively
4.53; 4.44
SECONDARY
Mean Opioid Consumption as Measured in Oral Morphine Milligram Equivalents
75.54; 68.78
SECONDARY
Mean Opioid Consumption as Measured in Oral Morphine Milligram Equivalents
75.54; 68.78
SECONDARY
Mean Opioid Consumption as Measured in Oral Morphine Equivalents
55.49; 44.47

Summary

Peripheral nerve blocks catheters of the femoral nerve have long been used for perioperative analgesia in total knee arthroplasty (TKA). These blocks provide effective analgesia and patient satisfaction for surgical pain relief. However, one of the main drawbacks to the femoral nerve block (FNB) is a denser motor block of the quadriceps muscle that can delay aggressive physical therapy and subsequent recovery from surgery. (1) Recently, there has been increasing interest in performing adductor canal blocks (ACB) with the aim of less motor blockade while providing commensurate analgesia compared to the FNB. (1,2) Current investigative reports have provided only preliminary data, and there is potential to change the standard of care for TKA as more data mounts in favor of ACBs. The goal of this study is to verify the analgesic equivalence of the two blocks, compare patient satisfaction, surgeon satisfaction, and physical therapy grading between the two blocks. Potentially, this would change the standard of care for TKA patients at this institution.

Eligibility Criteria

Inclusion Criteria

  • Patient undergoing total knee arthroplasty with regional anesthesia planned for postoperative analgesia.
  • Adult, 19 years of age or older
  • Patient classified as American Society of Anesthesiology (ASA) class I, II, or III

Exclusion Criteria

  • Any subject not classified as an ASA I, II, or III
  • Allergy/intolerance to local anesthetic
  • Pre-existing neurologic or anatomic deficit in lower extremity on the side of the surgical site
  • Coexisting coagulopathy such as hemophilia or von Willebrand disease
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03133481). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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