Phase 1
Completed N=18
Study of Danirixin in Japanese Healthy Elderly Male Subjects
Pulmonary Disease, Chronic Obstructive
Source: ClinicalTrials.gov NCT03136380 ↗
Enrolled (actual)
18
Serious AEs
0.0%
Results posted
Apr 2019
Primary outcomePrimary: Number of Participants With Any Adverse Event (AE) and Serious Adverse Events in Part 1 — 1; 0; 0; 1 Participants
Summary
Danirixin is a selective chemokine receptor antagonist being developed as a potential anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD). The aim of the study is to assess the safety, tolerability and pharmacokinetics (PK) in healthy Japanese subjects over the age of 65 years (inclusive). The study will be conducted in two parts: Part 1 will be a double blind, placebo-controlled, 3-period crossover, ascending single oral dose administration of GSK1325756H (Hydrobromide Salt Tablet Formulations of Danirixin) 10, 50 and 100 milligram (mg) in the fed condition. Part 2 will be an open label, 2-period crossover, single oral dose of GSK1325756H 50 mg in fed and fasted state. This study will provide an understanding of PK of hydrobromide salt of GSK1325756 in population of healthy elderly subjects and also contribute to the selection of appropriate dosing for Phase IIa study in Japan.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Any Adverse Event (AE) and Serious Adverse Events in Part 1 |
1; 0; 0; 1; 0; 0 | — |
| PRIMARY Number of Participants With Any Adverse Event (AE) and Serious Adverse Events in Part 2 |
1; 0; 0; 0 | — |
| PRIMARY Change From Baseline in Clinical Laboratory Parameters Calcium, Cholesterol, Chloride, Glucose, High Density Lipids (HDL) Cholesterol, Potassium, Low Density Lipids (LDL) Cholesterol,Sodium,Phosphorus,Triglycerides,Urea/Blood Urea Nitrogen (BUN) in Part 1 |
-0.0208; -0.0187; 0.0021; -0.0000; -0.0318; 0.0453 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Alkaline Phosphatase, Alanine Amino Transferase (ALT), Aspartate Amino Transferase (AST), Creatine Kinase, Gamma Glutamyl Transferase (GGT) and Lactate Dehydrogenase for Part 1 |
1.1; -1.5; 0.0; 12.5; 4.6; -2.2 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Albumin and Total Protein for Part 1 |
-0.3; -0.6; 0.3; 1.2; -1.0; 0.2 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Direct Bilirubin, Total Bilirubin, Creatinine and Uric Acid for Part 1 |
-0.428; 0.000; -0.712; -0.855; -0.466; -1.283 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameter Amylase for Part 1 |
16.0; 20.6; 22.7; 38.8; 14.4 | — |
| PRIMARY Change From Baseline in Clinical Laboratory Parameters Calcium, Cholesterol, Chloride, Glucose, HDL Cholesterol, Potassium, LDL Cholesterol, Sodium, Phosphorus Inorganic, Triglycerides, Urea/BUN for Part 2 |
0.0000; 0.0000; 0.3119; 0.3588; 0.2; 0.5 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Alkaline Phosphatase, ALT, AST, Creatine Kinase, GGT and Lactate Dehydrogenase for Part 2 |
0.9; 6.5; -1.5; -1.5; -2.0; -1.8 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Albumin and Total Protein for Part 2 |
0.3; 0.8; 1.1; 1.9 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameters Direct Bilirubin, Total Bilirubin, Creatinine and Uric Acid for Part 2 |
-0.641; -0.641; -1.496; -0.748; -2.8178; -4.2542 | — |
| PRIMARY Change From Baseline in Clinical Chemistry Parameter Amylase for Part 2 |
18.2; 18.5 | — |
| PRIMARY Change From Baseline in Hematology Parameters Basophils, Eosinophils, Lymphocytes, Monocytes and Total Neutrophils for Part 1 |
0.12; 0.09; 0.09; 0.13; 0.03; 1.39 | — |
| PRIMARY Change From Baseline in Hematology Parameter Hemoglobin for Part 1 |
3.7; 4.8; 5.5; 8.8; 5.0 | — |
| PRIMARY Change From Baseline in Hematology Parameter Hematocrit for Part 1 |
0.0188; 0.0177; 0.0238; 0.0255; 0.0121 | — |
| PRIMARY Change From Baseline in Hematology Parameter Mean Corpuscle Hemoglobin for Part 1 |
-0.32; -0.10; -0.14; 0.22; 0.25 | — |
| PRIMARY Change From Baseline in Hematology Parameter Mean Corpuscle Volume for Part 1 |
0.7; 0.3; 1.3; 0.2; 0.2 | — |
| PRIMARY Change From Baseline in Hematology Parameters Platelet Count and White Blood Cell Count for Part 1 |
3.7; 1.4; 0.5; 14.5; 2.3; -0.54 | — |
| PRIMARY Change From Baseline in Hematology Parameters Red Blood Count and Reticulocyte Count for Part 1 |
0.165; 0.164; 0.197; 0.252; 0.120; 0.0127 | — |
| PRIMARY Change From Baseline in Hematology Parameters Basophils, Eosinophils, Lymphocytes, Monocytes and Total Neutrophils for Part 2 |
-0.00; 0.09; 0.44; 0.67; 3.58; 4.53 | — |
| PRIMARY Change From Baseline in Hematology Parameter Hemoglobin for Part 2 |
9.4; 8.9 | — |
| PRIMARY Change From Baseline in Hematology Parameter Hematocrit for Part 2 |
0.0304; 0.0268 | — |
| PRIMARY Change From Baseline in Hematology Parameter Mean Corpuscle Hemoglobin for Part 2 |
-0.12; 0.20 | — |
| PRIMARY Change From Baseline in Hematology Parameter Mean Corpuscle Volume for Part 2 |
0.4; 0.6 | — |
| PRIMARY Change From Baseline in Hematology Parameters Platelet Count and White Blood Cell Count for Part 2 |
7.4; 13.1; 12.45; -0.36 | — |
| PRIMARY Change From Baseline in Hematology Parameters Red Blood Count and Reticulocyte Count for Part 2 |
0.318; 0.255; -0.0018; 0.0097 | — |
| PRIMARY Number of Participants With Abnormal Values on Urinalysis by Dipstick Method for Part 1 |
1; 1; 0; 0; 0; 1 | — |
| PRIMARY Urine Potential of Hydrogen (pH) Analysis by Dipstick Method for Part 1 |
6.42; 6.17; 6.42; 6.08; 6.36 | — |
| PRIMARY Urine Specific Gravity Analysis by Dipstick Method for Part 1 |
1.0167; NA; NA; 1.0150 | — |
| PRIMARY Number of Participants With Abnormal Values on Urinalysis by Dipstick Method for Part 2 |
1; 0; 1; 0; 0; 2 | — |
| PRIMARY Urine pH Analysis by Dipstick Method for Part 2 |
6.66; 6.47 | — |
| PRIMARY Urine Specific Gravity Analysis by Dipstick Method for Part 2 |
1.0153; 1.0159 | — |
| PRIMARY Change From Baseline in Vital Sign Parameters Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) for Part 1 |
-4.8; -9.6; -4.2; -0.3; 1.7; 0.5 | — |
| PRIMARY Change From Baseline in Vital Sign Parameter Heart Rate for Part 1 |
-3.1; -3.2; -3.7; -2.9; -3.0; -7.5 | — |
| PRIMARY Change From Baseline in Vital Sign Parameter Temperature for Part 1 |
0.11; 0.07; 0.27; 0.14; -0.08; 0.01 | — |
| PRIMARY Change From Baseline in Vital Sign Parameters SBP and DBP for Part 2 |
-1.5; -2.5; -2.8; -3.5; -1.9; -0.2 | — |
| PRIMARY Change From Baseline in Vital Sign Parameter Heart Rate for Part 2 |
-2.4; -1.8; 1.3; -0.1; 0.5; 0.5 | — |
| PRIMARY Change From Baseline in Vital Sign Parameter Temperature for Part 2 |
0.06; 0.21; 0.04; 0.10; 0.10; 0.10 | — |
| PRIMARY Change From Baseline in Electrocardiogram (ECG) Parameters PR Interval, QRS Duration, Uncorrected QT Interval and Corrected QT Frederica's Correction) Interval |
-0.9; 0.7; 1.3; 0.5; 2.3; 3.0 | — |
| PRIMARY Change From Baseline in Electrocardiogram Parameters PR Interval, QRS Duration, Uncorrected QT Interval and Corrected QT (Frederica's Correction) Interval for Part 2 |
-1.5; -0.6; -2.5; 1.3; 1.5; 4.1 | — |
| PRIMARY Blood Concentration of GSK1325756 in Part 1 |
0.000; 0.000; 0.000; 1.425; 9.289; 32.318 | — |
| PRIMARY Blood Concentration of GSK1325756 in Part 2 |
0.000; 0.000; 23.888; 434.557; 248.749; 2233.813 | — |
| PRIMARY Maximum Observed Concentration (Cmax) of GSK1325756H for Part 1 |
217.082; 1219.883; 1924.864 | — |
| PRIMARY Area Under the Concentration-time Curve From Time 0 to t (AUC [0-t]) of GSK1325756H for Part 1 |
1622.2891; 8872.6074; 16681.8331 | — |
| PRIMARY Area Under the Concentration-time Curve From Time 0 to Infinity (AUC [0-inf]) of GSK1325756H for Part 1 |
1779.0163; 9253.2108; 17072.6642 | — |
| PRIMARY Area Under the Concentration-time Curve From Time 0 to 24 Hours (AUC [0-24]) of GSK1325756H for Part 1 |
1500.0109; 7831.8861; 14000.5473 | — |
| PRIMARY Time to Maximum Observed Concentration (Tmax) of GSK1325756H for Part 1 |
3.50000; 3.00000; 4.00000 | — |
| PRIMARY Terminal Half-life (t1/2) of GSK1325756H for Part 1 |
10.53043; 11.17318; 13.15755 | — |
| PRIMARY Lag Time Before Observable Concentration (Tlag) of GSK1325756H for Part 1 |
0.37500; 0.25000; 0.25000 | — |
| PRIMARY Time to Last Quantifiable Concentration (Tlast) of the Blood Concentration of GSK1325756H for Part 1 |
36.00000; 48.00000; 72.00000 | — |
| PRIMARY Cmax of GSK1325756H for Part 2 |
1818.544; 4146.886 | — |
| PRIMARY AUC (0-t) of GSK1325756H for Part 2 |
11880.9038; 18303.0441 | — |
| PRIMARY AUC (0-inf) of GSK1325756H for Part 2 |
12143.8862; 18910.7975 | — |
| PRIMARY AUC (0-24) of GSK1325756H for Part 2 |
10433.9293; 16856.0664 | — |
| PRIMARY Tmax of GSK1325756H for Part 2 |
3.00000; 1.00000 | — |
| PRIMARY t1/2 of GSK1325756H for Part 2 |
10.75500; 11.09246 | — |
| PRIMARY Tlag of GSK1325756H for Part 2 |
0.25000; 0.00000 | — |
| PRIMARY Tlast of the Blood Concentration of GSK1325756H for Part 2 |
48.00000; 48.00000 | — |
Eligibility Criteria
Inclusion Criteria
- Participant must be over 65 years of age inclusive, at the time of signing the informed consent.
- Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and ECG. A subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the investigator in consultation with the Medical Monitor if required agree that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.
- Participants whose peripheral blood neutrophil counts and hematocrit values are within normal range at screening visit.
- Body weight >=50 kilogram (Kg) and body mass index (BMI) within the range 18.5-24.9 kg/square meter (m^2) (inclusive).
- Japanese Male: A male participant must agree to use contraception during the treatment period and until follow up visit.
- Capable of giving signed informed consent.
Exclusion Criteria
- History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study treatment; or interfering with the interpretation of data.
- Abnormal blood pressure as determined by the investigator.
- Alanine Aminotransferase (ALT)>1.5x upper limit of normal (ULN).
- Bilirubin>1.5xULN (isolated bilirubin > 1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin 450 millisecond (msec).
- Past or intended use of over-the-counter or prescription medication including herbal medications and proton pump inhibitor (PPI) within 14 days prior to dosing.
- History of donation of blood or blood products >=400 milliliter (mL) within 3 months or >=200 mL within 1 month prior to screening.
- Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day.
- Current enrolment or past participation within the last 30 days before signing of consent in this clinical study involving an investigational study treatment or any other type of medical research.
- The subject with positive Serological test for syphilis (Rapid Plasma Reagin [RPR] and Treponema pallidum hemagglutination test [TPHA]), Human immunodeficiency virus (HIV) Antigen/Antibody, Hepatitis B surface antigen (HBsAg), Hepatitis C virus (HCV) antibody, or Human T-cell lymphotropic virus type 1 (HTLV-1) antibody at screening.
- Positive pre-study drug screen.
- Regular alcohol consumption within 6 months prior to the study defined as: an average weekly intake of > 14 units for males. One unit is equivalent to 350 mL of beer, 150 mL of wine or 45 mL of 80 proof distilled spirits.
- Smoking or history or regular use of tobacco- or nicotine-containing products within 6 months prior to screening.
- Sensitivity to any of the study treatments, or components thereof, or drug or other allergy that, in the opinion of the investigator or medical monitor, contraindicates participation in the study.
Data sourced from ClinicalTrials.gov (NCT03136380). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.