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N/A N=41 Randomized Double-blind Basic Science

Impact of Theta Burst Stimulation Over the Left DLPFC on Language Switching

Languages

Bottom Line

View on ClinicalTrials.gov: NCT03148470 ↗
Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcome: Primary: RTs for Picture Naming With the Factors Language (L1, L2) and Block (Switching, Non-Switching) — 1103.32; 1107.26; 1098.82; 1158.91 Milliseconds — p=0.932

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Sham iTBS (Device); Sham cTBS (Device); intermittent theta burst stimulation (iTBS) (Device); continuous theta burst stimulation (cTBS) (Device)
Age
Adult · 18+ yrs
Sex
All
Sponsor
Jean-Marie Annoni
Primary completion
Jul 2018

Outcome Measures

OutcomeResultp-value
PRIMARY
RTs for Picture Naming With the Factors Language (L1, L2) and Block (Switching, Non-Switching)		 1103.32; 1107.26; 1098.82; 1158.91; 1081.14; 1175.24 0.932
SECONDARY
Nonverbal Switching		 772.07; 739.32 0.642

Summary

The purpose of this study is to investigate whether theta burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) influences language switching and cognitive flexibility. The experimental paradigm will assess the impact of inhibitory and excitatory prefrontal stimulation by TBS versus sham-TBS over the DLPFC in healthy bilinguals.

Eligibility Criteria

Inclusion Criteria

  • L1 (Swiss)German, knowledge of English as a foreign language
  • 18-45 years of age
  • right-handedness

Exclusion Criteria

  • epilepsy / family history of epilepsy
  • brain surgery, traumatic brain injuries
  • cardiac pacemaker, metallic objects in the head
  • history of neurological diseases or severe psychiatric disorders
  • drug use (alcohol, psychoactive medication)
  • strong headache
  • pregnancy
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03148470). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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