N/A
N=30
Effect of Local Anaesthetic Volume on Axillary Brachial Plexus Block Duration
Brachial Plexus Blockade
Bottom Line
View on ClinicalTrials.gov: NCT03163472 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcome: Primary: Overall Duration of Sensory Block. — 165; 188 minutes — p=<0.001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Axillary brachial plexus block with 10 mL oof local anaesthetic (Procedure); Axillary brachial plexus block with 30 ml of local anaesthetic (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Cork University Hospital
- Primary completion
- Aug 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overall Duration of Sensory Block. |
165; 188 | <0.001 sig |
| SECONDARY Duration of Motor Block |
165; 195 | 0.001 sig |
| SECONDARY Time to Onset of the Block |
15; 10 | 0.022 sig |
| SECONDARY Time to First Request of Postoperative Opioid Analgesia |
188; 267 | 0.011 sig |
| SECONDARY Opioid Consumption |
8.3; 6.3 | — |
| SECONDARY Number of Participants With Adverse Effects Perioperatively: Nausea, Dizziness, Tinnitus, Vomiting, Convulsions or Arrhythmia" |
0; 0 | — |
Summary
Axillary brachial plexus block is an safe, effective and widely used technique for providing surgical anesthesia at and below the elbow. Inadvertent intraneural and intravascular injections are the only significant risks. Traditionally, greater volumes of local anaesthetic have been administered to achieve successful axillary brachial plexus block, but recent studies have demonstrated that this can be achieved with even very low volumes of 2-4 mL lidocaine 1.5% per nerve or ultra low volume of 1 mL lidocaine 2% per nerve.
Administration of 30mL (vs 10 mL) lidocaine 2% with epinephrine 1:200 000 prolongs the sensory and motor block duration of ultrasound guided axillary brachial plexus block for elective upper limb surgical procedures.
Primary Outcome:
The primary outcome will be the overall duration of sensory block.
Secondary Outcomes:
Duration of motor block Time to onset of the block. The quality of block intraoperatively Time to first request of postoperative opioid analgesia. Total opioid consumption at 24 hours. The incidence of adverse effects perioperatively: nausea, dizziness, tinnitus, vomiting, convulsions or arrhythmia.
Eligibility Criteria
Inclusion Criteria
- ASA 1-3
- Patients aged >18 years
- undergoing elective upper limb (forearm, wrist or hand) surgical procedures.
Exclusion Criteria
- Contraindications to regional anaesthesia
- Hypersensitivity to amide local anaesthetics.
- Chronic pain
- Language barrier
- Neuromuscular disorders or peripheral neuropathy
- Body mass index > 35
- History of hepatic and renal insufficiency
- Pregnancy
- Cognitive or psychiatric disorder
- Cardiac conduction abnormality.
Data sourced from ClinicalTrials.gov (NCT03163472). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.