N/A
N=28
The Effect of Manipulation of the Cervical Spine on Pain Biomarkers
Neck Pain, Posterior
Bottom Line
View on ClinicalTrials.gov: NCT03176654 ↗Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcome: Primary: Plasma Concentration of Oxytocin — 154.5; 158.8 ug/ml
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- HVLAT manipulation (Procedure); Sham HVLAT manipulation (Procedure)
- Age
- Adult · 20+ yrs
- Sex
- Female
- Sponsor
- Loma Linda University
- Primary completion
- Sep 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plasma Concentration of Oxytocin |
185.1; 189.1 | — |
| PRIMARY Plasma Concentration of Oxytocin |
185.1; 189.1 | — |
| SECONDARY Plasma Concentration of Neurotensin |
136.4; 131.6 | — |
| SECONDARY Plasma Concentration of Neurotensin |
136.4; 131.6 | — |
| SECONDARY Plasma Concentration of Orexin A |
73.8; 67.3 | — |
| SECONDARY Plasma Concentration of Orexin A |
73.8; 67.3 | — |
| SECONDARY Plasma Concentration of Cortisol |
108.1; 139.7 | — |
| SECONDARY Plasma Concentration of Cortisol |
108.1; 139.7 | — |
Summary
This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and cortisol; and Examine the effect of HVLAT manipulation on pain perception in symptomatic females with non-specific mechanical cervical spine pain
Eligibility Criteria
Inclusion Criteria
- 20 - 45 years of age
- A score of 10 or more out of 50 on the Neck Disability Index (NDI) questionnaire
- Symptoms of pain present for 30 days or less and no pain symptoms below your shoulder
Exclusion Criteria
- Serious condition (such as cancer, spondylolisthesis, rheumatoid arthritis, or ankylosing spondylitis)
- Cervical spinal stenosis signs (such as incoordination in hands, arms and legs, inability of walking at a brisk pace, or bowel and bladder incontinence)
- Nerve root compression (such as changes in sensation, muscle weakness, or decreased reflexes)
- Works the night shift
- Steroid medication within 3 months
- Pregnancy or postpartum
- Pending legal action regarding their neck pain
- History of whiplash associated disorder and/or cervical spine surgery
Data sourced from ClinicalTrials.gov (NCT03176654). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.