Metoclopramide for Post Traumatic Headache
Summary
Linked Publications
-
Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable |
5.2; 3.8 | — |
| SECONDARY Sustained Headache Relief |
24; 18 | — |
| SECONDARY Headache Days |
3.3; 3.3 | — |
Eligibility Criteria
Inclusion Criteria
Included patients will be adults who meet International Classification of Headache Disorders criteria for acute post-traumatic headache. These are as follows:
- Traumatic injury to the head has occurred
- Headache has developed within 7 days of injury to the head
- Headache is not better accounted for by another diagnosis (eg, previous history of migraine or tension-type headache)
The headache must be rated as moderate or severe in intensity at the time of initial evaluation.
Exclusion Criteria
Patients will be excluded if more than ten days have elapsed since the head trauma, if the headache has already been treated with an anti-dopaminergic medication, or for medication contra-indications including pheochromocytoma, seizure disorder, Parkinson's disease, use of MAO inhibitors, and use of anti-rejection transplant medications.
Data sourced from ClinicalTrials.gov (NCT03220958) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.