N/A
N=121
Water Immersion and Polyp Detection: A Randomized Controlled Trial
Adenoma · Colonic Neoplasms
Bottom Line
View on ClinicalTrials.gov: NCT03231917 ↗Enrolled (actual)
121
Serious AEs
0.0%
Results posted
Jul 2019
Primary outcome: Primary: Adenoma Miss Rate — 52; 37 adenomas missed by first exam
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Water Infusion first (Procedure); CO2 Insufflation First (Procedure)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- White River Junction Veterans Affairs Medical Center
- Primary completion
- Aug 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Adenoma Miss Rate |
52; 37 | — |
| SECONDARY Patient-level Miss Rate |
27; 23 | — |
| SECONDARY Adenoma < 6mm Detection Rate |
45; 36 | 0.48 |
Summary
We plan to conduct a randomized trial of tandem colonoscopies comparing water infusion and air insufflation for inspection of mucosa on withdrawal. In one randomized group, water infusion will be employed as the first method for mucosal inspection while in a second group, CO2 insufflation will be used first. This study will be different than usual care since the participants will receive two successive or tandem colonoscopies versus one
Eligibility Criteria
Inclusion Criteria
- all adults 50 years or older who present for colonoscopy at White River Junction VAMC and Indiana University
Exclusion Criteria
- includes co-morbid status of ASA III or higher, Inflammatory Bowel Disease (IBD), surgical resection of the large bowel, as well as the use of anticoagulants. Finally, potential subjects who do not report a clear effluent in the most recent bowel movement will be excluded from the study.
Data sourced from ClinicalTrials.gov (NCT03231917). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.