N/A
Completed N=50
Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)
Infant,Premature
Source: ClinicalTrials.gov NCT03245723 ↗
Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Feb 2021
Primary outcomePrimary: Cardiac Glucose Uptake During Normoxic Rest (µg/Min) — 0.689; 0.540 µg/min — p=0.38
Summary
The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cardiac Glucose Uptake During Normoxic Rest (µg/Min) |
0.689; 0.540 | 0.38 |
| PRIMARY Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min) |
-0.264; -0.003 | 0.12 |
Eligibility Criteria
Inclusion Criteria
- National Lung Project Cohort only- birth weight <1500g and a gestational age <36 weeks
- Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
- Healthy Controls only- No personal history of known cardiovascular or pulmonary disease
Exclusion Criteria
- Metabolic Disorders that would affect Fludeoxyglucose uptake
- Contraindications to positron emission tomography and/or magnetic resonance imaging
- Pregnancy, if a female of child-bearing potential
- A personal history of Type I or Type II diabetes
Data sourced from ClinicalTrials.gov (NCT03245723). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.