N/A
N=50
Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)
Infant,Premature
Bottom Line
View on ClinicalTrials.gov: NCT03245723 ↗Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Feb 2021
Primary outcome: Primary: Cardiac Glucose Uptake During Normoxic Rest (µg/Min) — 0.689; 0.540 µg/min — p=0.38
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Pulmonary Function Testing (Procedure); Electrocardiogram (Procedure); Positron Emission Tomography (Procedure); Magnetic Resonance Imaging (Procedure)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Wisconsin, Madison
- Primary completion
- Feb 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cardiac Glucose Uptake During Normoxic Rest (µg/Min) |
0.689; 0.540 | 0.38 |
| PRIMARY Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min) |
-0.264; -0.003 | 0.12 |
Summary
The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.
Eligibility Criteria
Inclusion Criteria
- National Lung Project Cohort only- birth weight <1500g and a gestational age <36 weeks
- Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
- Healthy Controls only- No personal history of known cardiovascular or pulmonary disease
Exclusion Criteria
- Metabolic Disorders that would affect Fludeoxyglucose uptake
- Contraindications to positron emission tomography and/or magnetic resonance imaging
- Pregnancy, if a female of child-bearing potential
- A personal history of Type I or Type II diabetes
Data sourced from ClinicalTrials.gov (NCT03245723). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.