N/A
Completed N=125
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
Osteoarthritis, Knee
Source: ClinicalTrials.gov NCT03261505 ↗
Enrolled (actual)
125
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcomePrimary: fMRI Signal Increases — .42; .48; .47; .33 beta value of bold signal
Summary
The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the underlying brain mechanisms of mind-body interaction, imagery, and acupuncture.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY fMRI Signal Increases |
.42; .48; .47; .33 | — |
| SECONDARY PAG Resting State Connectivity |
.09; .09; .1; .08 | — |
Eligibility Criteria
Inclusion Criteria
- Right-handed
- Knee osteoarthritis patients
- Ages 40 to 70 years old
Exclusion Criteria
- Any contraindications to MRI scanning (claustrophobia, metal implants)
- Current or past history of major medical, neurological, or psychiatric illness other than knee osteoarthritis (including high blood pressure, heart disorders, impaired elimination, stomach problems, major kidney or liver problems, bleeding problems, severe dehydration, history of diabetes, history of asthma or other respiratory condition)
- Pregnancy
- Non fluent English speaker
Data sourced from ClinicalTrials.gov (NCT03261505). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.