N/A
N=105
Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force
Healthy Adults · Genetic Predisposition to Disease
Bottom Line
View on ClinicalTrials.gov: NCT03276637 ↗Enrolled (actual)
105
Serious AEs
0.0%
Results posted
May 2021
Primary outcome: Primary: Active-duty Airmen's Perceptions About Military Use of Genomic Information to Make Career Decisions — 2.62; 2.66 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Whole exome sequencing (Genetic)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Brigham and Women's Hospital
- Primary completion
- Jun 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Active-duty Airmen's Perceptions About Military Use of Genomic Information to Make Career Decisions |
2.62; 2.66 | — |
| PRIMARY Genomic Sequencing Findings |
11; 64; 65; 10; 37; 38 | — |
| PRIMARY Active-duty Airmen Reported Health Care Utilization Related to Study Results |
9; 7; 5; 5; 1; 56 | — |
| PRIMARY Military Healthcare Providers' Genomic Literacy |
9.92; 11.50; 10.75 | — |
| SECONDARY Active-duty Airmen Attitudes and Perceived Utility Toward Genomic Sequencing |
14.31; 14.10; 7.76; 7.30 | — |
| SECONDARY Active-duty Airmen's Health Perceptions |
3.95; 3.86 | — |
| SECONDARY Military Healthcare Providers' Confidence With Genomic Data |
7.25; 13.00; 12.33 | — |
Summary
The MilSeq Project is a nonrandomized, prospective pilot study of whole exome sequencing (WES) in the U.S. Air Force. The purpose of this study is to explore the implementation of WES into clinical medical care in the military health system.
Eligibility Criteria
Patient-Participant Inclusion Criteria:
- 18 years or older
- An active Air Force Airman
- Fluent in English
- Seen or eligible to be seen by a provider at Wilford Hall Ambulatory Surgical Center at Joint Base San Antonio (JBSA) Lackland Air Force Base
Healthcare Provider-Participant Inclusion Criterion
- An active or Department of Defense civilian Primary Care, Internal Medicine, or Family Practice Healthcare Provider (Physician, Physician Assistant, or Nurse Practitioner) or resident practicing at Wilford Hall Ambulatory Surgical Center at JBSA Lackland Air Force Base
Patient-Participant Exclusion Criteria:
- Those who do not meet the above inclusion criteria
- Those with clinically concerning scores on anxiety and distress scales in baseline survey
- Trainees (basic military training or tech school)
- Airmen with an active change of duty station order or deployment order and expected to leave San Antonio in 6 months or less
- Airmen expected to be discharged from the Air Force in 6 months or less
Healthcare Provider-Participant Exclusion Criteria:
- Providers who do not meet the above inclusion criteria
- Providers with an active change of duty station order or deployment order and expected to leave San Antonio in 6 months or less
- Providers expected to be discharged from the Air Force in 6 months or less
Data sourced from ClinicalTrials.gov (NCT03276637). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.