Phase 4
Completed N=141
Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting
Post-operative Nausea and Vomiting
Source: ClinicalTrials.gov NCT03297021 ↗
Enrolled (actual)
141
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcomePrimary: Nausea Scale — 3.5; 4.0; 4.0; 2.0 score on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Nausea Scale |
3.5; 4.0; 4.0; 2.0; 1.0; 8.0 | — |
| SECONDARY Number of Participants With Episodes of Vomiting in the PACU |
2; 0; 1 | — |
| SECONDARY Number of Participants With Symptoms on POD 1 |
9; 4; 1; 1; 1; 0 | — |
| SECONDARY Number of Participants Who Needed Rescue Anti-emetics |
4; 1; 2 | — |
| SECONDARY Total Anesthesia Time |
116.0; 128.5; 118.0 | — |
Eligibility Criteria
Inclusion Criteria
- ASA I, II, III presenting for ambulatory surgery to be performed under general anesthesia
Exclusion Criteria
- Patients with allergies or contraindications to study medications
Data sourced from ClinicalTrials.gov (NCT03297021). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.