Phase 4
Completed N=15
Sedative-Anxiolytic Effects on Simulated Driving Performance
Psychomotor Impairment
Source: ClinicalTrials.gov NCT03297944 ↗
Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Jan 2020
Primary outcomePrimary: Standard Deviation of Lane Position (SLDP) — 40.08; 37.28; 36.06; 37.61 distance (cm)
◆ Published Evidence
Not yet cited
0citations
Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.
Summary
This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.
Linked Publications
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Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Standard Deviation of Lane Position (SLDP) |
40.08; 37.28; 36.06; 37.61; 36.30; 40.72 | — |
Eligibility Criteria
Inclusion Criteria
- valid driver's license
- english-speaking and literate
Exclusion Criteria
- using daily medication for chronic condition
- acute narrow angle glaucoma
- previous adverse experience with study drugs
- experiences motion sickness in response to driving simulator
- BMI > 30
- women who are pregnant, lactating, or planning on becoming pregnant
- regular use of tobacco products
- current substance use disorder
- clinically significant ECG
- current ongoing psychiatric disorder
Data sourced from ClinicalTrials.gov (NCT03297944) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.