N/A
N=12
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
Pain Management
Bottom Line
View on ClinicalTrials.gov: NCT03302793 ↗Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Jan 2019
Primary outcome: Primary: Pain as Assessed by Visual Analogue Scale (VAS) — 6.0; 5.9; 5.4; 5.3 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- BreEStim (Device); tDCS (Device); tDCS sham (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The University of Texas Health Science Center, Houston
- Primary completion
- Dec 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain as Assessed by Visual Analogue Scale (VAS) |
6.0; 5.9; 5.4; 5.3; 3.5; 3.1 | — |
| SECONDARY Electrical Pain Threshold |
30.4; 35.0; 31.1; 33.9; 34.5; 35.2 | — |
| SECONDARY Electrical Sensation Threshold |
7.3; 8.4; 7.4; 8.1; 7.3; 8.3 | — |
Summary
This study looks at the effect of combined breathing-controlled electrical stimulation (BreEStim) and transcranial direct current stimulation (tDCS) on neuropathic pain after spinal cord injury, amputation, or brain injury. The hypothesis is that a single session of combined BreEStim and tDCS will produce an additive analgesic effect. This record covers the study in a population of spinal cord injury patients. Note that this study will also enroll healthy volunteers, brain injury patients, and amputation patients and that this study as applied to these other populations will be covered in separate ClinicalTrials.gov records.
Eligibility Criteria
Inclusion Criteria
- between 18 and 75 years
- male and female subjects
- has neuropathic pain after traumatic spinal cord injury
- has chronic pain, >3 months
- is stable on oral pain medications at least two weeks. (patients are allowed to continue their pain medications, i.e., no change in pain medications.)
Exclusion Criteria
- currently adjusting oral pain medications for their neuropathic pain
- have pain, but not neuropathic (e.g., from inflammation at the incision wound of the residual limb or neuroma)
- have a pacemaker, or other metal and/or implanted devices
- have amputation in their arm(s)
- have spinal cord injury (SCI) involving impairment of arms
- have cognitive impairment from brain injury or are not able to follow commands, or to give consent
- have asthma or other pulmonary disease
- are not medically stable
- have preexisting psychiatric disorders
- alcohol or drug abuse
- have a history of seizures/Epilepsy, or taking benzodiazepines, anticonvulsants, and antidepressants.
- Mini-mental state examination (MMSE), a brief 30-point questionnaire test that is commonly used in the literature, will be used to screen for cognitive impairment. A brain injury patient with a score of 24 or lower on MMSE will be excluded.
Data sourced from ClinicalTrials.gov (NCT03302793). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.