Mavoglurant in Alcohol Drinking

Inclusion Criteria

• Ages 21-50
• Able to read English at 6th grade level or higher and to complete study evaluations
• Social drinkers
• Willing to abstain from drinking alcohol during the outpatient study medication treatment period

Exclusion Criteria

• Seeking treatment for alcohol drinking
• Current DSM-V criteria for any other substances, other than alcohol or nicotine.
• Positive test results at any appointments after the initial intake appointment on urine drug screens conducted for opiates, cocaine, marijuana, benzodiazepines and/or barbiturates.
• Regular use of psychoactive drugs including anxiolytics and antidepressants.
• Psychotic or otherwise severely psychiatrically disabled.
• Any medical conditions (including hepatic and renal impairment) that would contraindicate the consumption of alcohol or administration of mavoglurant.
• History of neurological trauma or disease, delirium, or hallucinations, or any significant systemic illness or unstable medical condition.
• Women who are pregnant, nursing, or refuse to use a reliable method of birth control. Urine pregnancy tests will be completed at intake and prior to administration of alcohol at each lab session.
• Subjects who report disliking spirits will be excluded because hard liquor will be provided during the alcohol administration.
• Subjects who have taken any investigational drug and/or participated in another study which involves additive blood sampling and/or interventional measures that would be considered excessive in combination with the current protocol within 4 weeks immediately preceding admission to the treatment period.
• Subjects who report any daily drug use during the 30 days prior to randomization for the following: anxiolytics, beta blockers, central nervous system stimulants, hypnotics, non-therapeutic doses of neuroleptics and antidepressants, drugs with psychotropic activity or drugs which cause excessive sedation.
• Subjects who have donated blood within the past six weeks.
• Current use (within 30 days of screening) of specific psychoactive medications (e.g., typical neuroleptics, narcotic analgesics, antiparkinsonian medications, systemic corticosteroids, or medications with significant central anticholinergic activity, etc
• Current use of warfarin.
• Use of any medications that are contraindicated with mavoglurant and alcohol.
• AST, ALT, total bilirubin >1.5 times upper normal; serum creatinine, >2 times upper normal limit, total bilirubin>1.5 times ULN; Serum creatinine >2.0 times ULN.