N/A
N=146
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
Risk-Taking · Adolescent Behavior
Bottom Line
View on ClinicalTrials.gov: NCT03370393 ↗Enrolled (actual)
146
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcome: Primary: Changes in Emotional Regulation — 54.43; 52.02; 54.47; 60.77 T Score — p=0.003
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Pathways for African-Americans' Success (PAAS) (Behavioral)
- Age
- Pediatric · 11+ yrs
- Sex
- All
- Sponsor
- University of California, Irvine
- Primary completion
- Mar 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Emotional Regulation |
54.43; 52.02; 54.47; 60.77 | 0.003 sig |
| SECONDARY Changes in Cognitive Regulation |
55.41; 54.51; 51.81; 55.66 | 0.45 |
Summary
Adolescence is a time of biological and behavioral changes that can lead to risky and dangerous behaviors, and African-American youth are highly vulnerable to the consequences of risky behavior, including HIV/AIDS and violence, leading to premature death. The investigators previously showed that an intervention program reduces HIV-risk vulnerability behaviors in many African-American youth. The investigators aim to measure how the program affects different regions of the brain in order to better prevent or reduce such risky behaviors among African-American youth.
Eligibility Criteria
Inclusion Criteria
- Subject is of African-American racial status (self-reported)
- Subject can speak and read English
- Subject and parent/legal guardian agree to participate in the 6-week PAAS program
- Subject and parent/legal guardian agree to complete all assessments
- Subject must meet MRI safety eligibility
Exclusion Criteria
- Subject has a major medical problem (e.g. neurological disorders)
- Subject is on medication(s) that affects the central nervous system
- Subject has behavioral/emotional problems at a clinical level (parent and/or youth report)
- Subject is pregnant or suspected of being pregnant (based on pregnancy test)
- Subject is color-blind
- Subject has claustrophobia
- Subject has metallic implants
- Subject drinks alcohol in the week prior to entry into the study (based on urine drug screen)
- Subject uses drugs in the week prior to entry into the study (based on urine drug screen)
Data sourced from ClinicalTrials.gov (NCT03370393). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.