N/A
N=196
Prevention and Risk: Treatment With a New Emphasis on Relationships
Adherence, Medication · Risk Reduction · Drug Use · Sex, Anal · HIV/AIDS
Bottom Line
View on ClinicalTrials.gov: NCT03396367 ↗Enrolled (actual)
196
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Illicit Drug Use Days — 1.49; .80; 1.16; 0.83 days — p=.433
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- PARTNER (Behavioral); Education Intervention (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- Male
- Sponsor
- Hunter College of City University of New York
- Primary completion
- Feb 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Illicit Drug Use Days |
1.49; .80; 1.16; 0.83; .67; .56 | .433 |
| PRIMARY Cannabis Use Days |
9.68; 7.59; 9.28; 7.49; 9.13; 7.27 | .172 |
| PRIMARY Number (Proportion) of Participants Who Report Sexual HIV Transmission Risk With Casual Partners |
16; 16; 8; 10; 5; 5 | .679 |
| PRIMARY The Number (Proportion) of Participants Reporting Pre-Exposure Prophylaxis (PrEP) Uptake |
50; 58; 42; 51; 50; 47 | .326 |
Summary
This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention - termed PARTNER - utilizes a brief (4 session) motivational interviewing format to target Pre-Exposure Prophylaxis (PrEP) uptake/adherence, HIV transmission risk behavior, and associated drug use.
Eligibility Criteria
Inclusion Criteria
- 18 to 29 years of age (inclusive);
- Main partner must be aged 18 or older.
- Must be in a main partner relationship with another male (duration ≥ 1 months);
- HIV-negative serostatus (confirmed by rapid test);
- Recent (past 30 day) use of at least one of the substances identified as most commonly used by YMSM (marijuana, cocaine, methamphetamine, heroin or other opiates, MDMA, psychedelics, GHB, and/or ketamine);
- Sexual behavior meeting CDC criteria for PrEP candidacy (TRB with a casual partner in the past 30 days or TRB with a non-monogamous or serodiscordant main partner).
- Participants must reside in the NYC metro area
- Ability to communicate in English
Exclusion Criteria
- Unstable, serious psychiatric symptoms (assessed by the Psychotic Disorder subsection of the Structured Clinical Interview for DSM-IV);
- Current suicidal/homicidal ideation;
- Evidence of gross cognitive impairment (a score of <24 on the mini-mental state examination)
- A history of severe physical or sexual Intimate Partner Violence (IPV) victimization in the current relationship in which participants report not currently feeling "safe" in their relationship and/or coerced to participate in the study.
Data sourced from ClinicalTrials.gov (NCT03396367). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.