Phase 3
Completed N=80
Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty
Source: ClinicalTrials.gov NCT03408483 ↗Enrolled (actual)
80
Serious AEs
0.0%
Results posted
Sep 2020
Primary outcomePrimary: Pain Scores Using Visual Analog Scale (VAS) Scores — 2.34; 3.33 units on a scale
◆ Published Evidence
Highly cited
118citations · ~17 / year
Anterior quadratus lumborum block analgesia for total hip arthroplasty: a randomized, controlled study.
Summary
Peripheral nerve blocks for joint and extremity surgeries have long been proven to provide effective post-operative analgesia. Of these surgeries, total hip arthroplasty (THA) remains one of the most common orthopedic procedures in the United States with approximately 300,000 operations performed annually. At our institution, post-operative analgesia in these patients is primarily provided through parenteral and oral opioid medications. Quadratus lumborum blocks (QLB) have been described and implemented for various surgical procedures including caesarean and laparoscopic ovarian surgery. Recently, there has been increasing interest in the efficacy of quadratus lumborum blocks for THA. Currently, case reports have established a precedent regarding the efficacy of the QLB for THA in providing superior analgesia and decreasing visual analog pain scores (VAS), but randomized trials are still lacking. The goal of this study is to compare pain scores (VAS), opioid consumption, physical therapy scores, and patient and surgeon satisfaction in patients that receive QLB versus no peripheral nerve blockade in patients undergoing THA. The results of this study have the potential to change standard of care for patients undergoing THA.
Linked Publications
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Anterior quadratus lumborum block analgesia for total hip arthroplasty: a randomized, controlled study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Scores Using Visual Analog Scale (VAS) Scores |
2.34; 3.33 | — |
| PRIMARY Opioid Consumption (Oral Morphine Equivalents) |
54.63; 90.76 | — |
| SECONDARY Patient Satisfaction |
9.14; 7.46 | — |
| SECONDARY Hours to Hospital Discharge |
53.17; 55.97 | — |
| SECONDARY Distance Ambulated |
114.51; 100.85 | — |
Eligibility Criteria
Inclusion Criteria
- Patients undergoing total hip arthroplasty
- Adults 18 years of age and older
- Patients with an American Society of Anesthesiology (ASA) physical status classification of I, II or III
Exclusion Criteria
- Patients with ASA physical status classification other than I, II, or III
- Patients with allergies/intolerances to local anesthetic
- Patients with pre-existing neurologic or anatomic deficits in the lower extremity on the side of the surgical site
- Patients with coexisting coagulopathy
- Patients that are pharmacologically anticoagulated will be excluded if placement of peripheral nerve block would be contraindicated according to ASRA (American Society for Regional Anesthesia) guidelines or if spinal anesthesia would be contraindicated according to guidelines
Data sourced from ClinicalTrials.gov (NCT03408483) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.