N/A N=180 Randomized Double-blind Prevention

MINDSpeed Food and Brain Training RCT

Low Education · Cognition · Cognitive Training · Polyphenols

Bottom Line

View on ClinicalTrials.gov: NCT03419052 ↗

Enrolled (actual)

180

Serious AEs

35.6%

Results posted

Mar 2025

Primary outcome: Primary: Executive Cognitive Function Composite Score — 0.211; 0.100; 0.142; 0.196 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Speed of processing training (Behavioral); MIND foods (Behavioral); Cognitive training control (Behavioral); Control foods (Behavioral)
Age: Adult, Older Adult · 60+ yrs
Sex: All
Sponsor: Indiana University
Primary completion: Mar 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Executive Cognitive Function Composite Score	0.211; 0.100; 0.142; 0.196	—

Summary

The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance

Eligibility Criteria

Inclusion criteria

age 60 years or older,
≤ 12 years of education,
English speaking,
Marion County (and immediately surrounding counties) resident, with steady/fixed residence to receive food deliveries
natural-born US citizen.

Exclusion criteria

living in nursing home
self-reported diagnosis of dementia, Alzheimer's disease (AD), cancer with short life expectancy, multiple sclerosis, epilepsy, schizophrenia, bipolar disorder, Parkinson disease; current chemotherapy or radiation therapy; history of brain tumor, brain surgery, brain infection; stroke or myocardial infarction within the past 12 months
current alcohol consumption ≥8 drinks per week for women or ≥15 drinks per week for men;
poor vision (self-reported difficulty reading a newspaper) or color blind;
low communicative ability (examiner rated) that would interfere with interventions and assessments;
prior involvement in similar cognitive training studies;
unable or unwilling to provide blood sample at Baseline
tumor, hemorrhage, aneurysm, hydrocephalus, or other significant clinical finding from Baseline brain MRI

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03419052). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.