Phase 3
Completed N=87
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds
Wound of Skin · Wound Heal · Wound Open · Surgical Wound
Source: ClinicalTrials.gov NCT03452072 ↗
Enrolled (actual)
87
Serious AEs
0.0%
Results posted
May 2026
Primary outcomePrimary: Number of Participants With Re-epithelialization at 30 Days Post op — 9; 12 participants — p=0.580
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature. The investigators will enroll 114 patients who have their skin cancer surgically removed resulting in open surgical wounds less or equal to 1.5 cm. The objective of this randomized safety study is to determine the safety and efficacy of 0.25% timolol in promoting wound healing in open surgical wounds less or equal to 1.5 cm.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Re-epithelialization at 30 Days Post op |
9; 12 | 0.580 |
| SECONDARY Cosmetic Outcomes of Open Surgical Wound Healing by Blinded Physician Vancouver Scar Scale Assessment |
8.8; 8.8 | — |
| SECONDARY Study Subject Complete the Patient Scar Assessment Via Visual Analogue Scale |
5.71; 5.97 | — |
| SECONDARY Number of Participants Whose Side Effects Are Associated With 0.25% Topical Timolol for Open Surgical Wounds |
1; 0 | — |
Eligibility Criteria
Inclusion Criteria
- Age greater than 18 years
- Open surgical wound ≤1.5cm
- No hypersensitivity with use of 0.25% timolol gel
Exclusion Criteria
- Age less than 18 years of age
- Open surgical wound >1.5cm
- Pregnant women
- Use of systemic retinoids within 1 month
- Any hypersensitivity with use of 0.25% timolol gel
Data sourced from ClinicalTrials.gov (NCT03452072). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.