Phase 4
Completed N=120
Preoperative IV Versus Oral Acetaminophen
Pain, Postoperative
Source: ClinicalTrials.gov NCT03468920 ↗
Enrolled (actual)
120
Serious AEs
0.0%
Results posted
May 2019
Primary outcomePrimary: Patient Reported Pain — 4.12; 4.37 score on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The current study proposes to examine whether there is a significant difference in patient outcomes related to the administration route of preoperative Acetaminophen. Specifically, the study will compare outcomes of surgical patients who receive IV Acetaminophen with surgical patients who receive oral Acetaminophen.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Patient Reported Pain |
4.12; 4.37 | — |
| SECONDARY Number of Participants Who Received Opioid Administration in PACU |
31; 34 | — |
| SECONDARY Number of Participants Who Experienced Postoperative Nausea and Vomiting |
8; 6 | — |
| SECONDARY Length of Stay |
88.25; 92.88 | — |
| SECONDARY Patient Satisfaction |
9.45; 9.77 | — |
Eligibility Criteria
Inclusion Criteria
- 18 years old or older
- Admitted to Bethesda Butler Main Perioperative Services for an outpatient surgical procedure performed under general anesthesia
Exclusion Criteria
- Allergy to Acetaminophen
- Lactose intolerance or lactose allergy (placebo capsules contain lactose)
- Hepatic disease
- Having taken a product containing acetaminophen within 6 hours of scheduled surgery time
- Pregnant
- Weight less than 50kg
- Opioid addiction - admits to current opioid addiction and/or substance abuse disorder, and/or currently in treatment for opioid addiction or substance abuse
- Emergent or on-call procedures
- Inpatient surgery
Data sourced from ClinicalTrials.gov (NCT03468920). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.