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Phase 4 Completed N=32 Randomized Treatment

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Pleural Infection · Empyema · Pleural Diseases · Parapneumonic Effusion
Source: ClinicalTrials.gov NCT03468933 ↗
Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Feb 2021
Primary outcomePrimary: Duration of Hospital Stay After Intervention — 4; 2 days
◆ Published Evidence
No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complicated parapneumonic effusion (CPPE) in adults.

Outcome Measures

OutcomeResultp-value
PRIMARY
Duration of Hospital Stay After Intervention
4; 2
SECONDARY
Total Length of Hospital Stay
6; 3.5
SECONDARY
Number of Participants Necessitating Intervention After the Assigned Treatment
3; 4
SECONDARY
Adverse Events
1; 1
SECONDARY
In Hospital and 30-day Mortality
0; 1

Eligibility Criteria

Inclusion Criteria

Subjects >18 years old with:

Evidence of empyema or complex parapneumonic effusion

Exclusion Criteria

Age <18 years Pregnancy Inability to give informed written consent Previous thoracic surgery or thrombolytic therapy for pleural infection Medical thoracoscopy cannot be performed within 48 hours Hemodynamic instability or severe hypoxemia Non corrected coagulopathy Homogeneously echogenic effusion on pleural ultrasonography

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03468933). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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