N/A
N=19
Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)
Motor Activity · Motor Neuroplasticity
Bottom Line
View on ClinicalTrials.gov: NCT03481309 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcome: Primary: Changes in Motor-evoked Potentials Ratios — 1.32; 0.73; 1.03 Ratio (unit: uV)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- anodal tDCS (Device); cathodal tDCS (Device); sham tDCS (Device)
- Age
- Adult · 18+ yrs
- Sex
- Male
- Sponsor
- University of North Carolina, Chapel Hill
- Primary completion
- Jan 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Motor-evoked Potentials Ratios |
1.32; 0.73; 1.03 | — |
| PRIMARY Changes in TMS-evoked Potentials Ratios |
1.5; 0.8; 1.1 | — |
| SECONDARY Changes in Resting-state EEG Dynamics Ratios |
1.2; 0.8; 1.1 | — |
Summary
Investigating modulation of motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation.
Eligibility Criteria
Inclusion Criteria
- Male
- Between the ages of 18 and 35
- Right-handed
- Capacity to understand all relevant risks and potential benefits of the study (informed consent)
- Willing to comply with all study procedures and be available for the duration of the study
- Speak and understand English
Exclusion Criteria
- Prior concussion
- Diagnosis of eating disorder (current or within the past 6 months)
- Diagnosis of obsessive compulsive disorder (lifetime)
- Attention-deficit/hyperactivity disorder (currently under treatment)
- Neurological disorders and conditions, including, but not limited to:
- History of epilepsy
- Seizures (except childhood febrile seizures and electroconvulsive therapy-induced seizures)
- Dementia
- History of stroke
- Parkinson's disease
- Multiple sclerosis
- Cerebral aneurysm
- Brain tumors
- Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
- Prior brain surgery
- Any brain devices/implants, including cochlear implants and aneurysm clips
- Traumatic brain injury
- Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
Data sourced from ClinicalTrials.gov (NCT03481309). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.