Phase 2 N=12 Basic Science

EEG Studies of Sevoflurane-Induced General Anesthesia

Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT03503578 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2019

Primary outcome: Primary: Frequencies At Which Changes in Alpha, Theta, and Slow-Delta Wave Power Were Observed From Baseline During Sevoflurane-induced General Anesthesia — 10; 5; 1 Hz

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Sevoflurane (Drug); Ketamine (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Massachusetts General Hospital
Primary completion: Aug 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Frequencies At Which Changes in Alpha, Theta, and Slow-Delta Wave Power Were Observed From Baseline During Sevoflurane-induced General Anesthesia	10; 5; 1	—

Summary

The investigators are performing this research study to find out how and where the anesthetic drugs sevoflurane and ketamine act in the brain. Sevoflurane and ketamine are anesthetics (a drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness). The investigators will study the brain using a machine that records the brain's electrical activity, called an electroencephalogram (EEG).

Eligibility Criteria

Inclusion Criteria

Between the ages of 18 and 50
Normal body weight and habitus, BMI ≤ 30
Non-smoker
American Society of Anesthesiologists (ASA) physical status classification P1

Exclusion Criteria

Chronic health conditions

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03503578). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.