Phase 1
Completed N=34
Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults
Healthy, Young Adults
Source: ClinicalTrials.gov NCT03512028 ↗
Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Feb 2020
Primary outcomePrimary: One-repetition Maximum of Wrist Extensors — 22.6; 23.7; 32.0; 29.9 lbs — p=0.002
Summary
The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can enhance learning of a motor (balance) and an ecologically valid, complex cognitive-motor (driving) task, and increase skeletal muscle strength in neurologically-intact young adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY One-repetition Maximum of Wrist Extensors |
22.6; 23.7; 32.0; 29.9; 30.8; 29.2 | 0.002 sig |
Eligibility Criteria
Inclusion Criteria
- Healthy adults between the age of 18 and 40 years
- Visual acuity of 20/20 with corrected vision
Exclusion Criteria
- History of neurological condition (i.e. stroke, Alzheimer's disease, Parkinson's disease), Attention Deficit Hyperactivity Disorder (ADHD), depression, bipolar disorder, balance impairment, or vestibular disorder
- History of severe motion sickness, moderate to severe motion sickness or nausea on oculo-motor components of Simulator sickness questionnaire, inability to ride a car, boat, train or airplane due to motion sickness
- Recent wrist, hand or forearm injury that would currently prevent ability to lift weights
- History of lower extremity condition, injury, or surgery that would currently impair ability to stand or balance
- Any extremity soft tissue, orthopedic, or vascular injury (i.e. peripheral vascular disease) which may contraindicate RLIC
- Any cognitive, sensory, or communication problem that would prevent completion of the study
- History of or current sleep apnea
- Current intensive weight lifting or interval training exercise
- Current substance abuse or dependence
- Unwillingness to travel for all study visits
Data sourced from ClinicalTrials.gov (NCT03512028). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.