Phase 1 N=34 Randomized Single-blind Treatment

Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults

Healthy, Young Adults

Bottom Line

View on ClinicalTrials.gov: NCT03512028 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2020

Primary outcome: Primary: One-repetition Maximum of Wrist Extensors — 22.6; 23.7; 32.0; 29.9 lbs — p=0.002

Study Design & Population

Study type: Interventional
Phase: Phase 1
Interventions: RLIC (Behavioral); Sham conditioning (Behavioral); Muscle strength training (Behavioral); Driving training (Behavioral); Balance training (Behavioral)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Washington University School of Medicine
Primary completion: Dec 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY One-repetition Maximum of Wrist Extensors	22.6; 23.7; 32.0; 29.9; 30.8; 29.2	0.002 sig

Summary

The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can enhance learning of a motor (balance) and an ecologically valid, complex cognitive-motor (driving) task, and increase skeletal muscle strength in neurologically-intact young adults.

Eligibility Criteria

Inclusion Criteria

Healthy adults between the age of 18 and 40 years
Visual acuity of 20/20 with corrected vision

Exclusion Criteria

History of neurological condition (i.e. stroke, Alzheimer's disease, Parkinson's disease), Attention Deficit Hyperactivity Disorder (ADHD), depression, bipolar disorder, balance impairment, or vestibular disorder
History of severe motion sickness, moderate to severe motion sickness or nausea on oculo-motor components of Simulator sickness questionnaire, inability to ride a car, boat, train or airplane due to motion sickness
Recent wrist, hand or forearm injury that would currently prevent ability to lift weights
History of lower extremity condition, injury, or surgery that would currently impair ability to stand or balance
Any extremity soft tissue, orthopedic, or vascular injury (i.e. peripheral vascular disease) which may contraindicate RLIC
Any cognitive, sensory, or communication problem that would prevent completion of the study
History of or current sleep apnea
Current intensive weight lifting or interval training exercise
Current substance abuse or dependence
Unwillingness to travel for all study visits

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03512028). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.