Phase 4
Completed N=71
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
Sickle Cell Anemia Crisis
Source: ClinicalTrials.gov NCT03541980 ↗
Enrolled (actual)
71
Serious AEs
0.0%
Results posted
Apr 2021
Primary outcomePrimary: Cumulative Opioid Dosing — .2; .2 mg/kg
◆ Published Evidence
Emerging
16citations · ~3 / year
Does Intravenous Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients With Acute Sickle Cell Crises?
Summary
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
Linked Publications
-
Does Intravenous Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients With Acute Sickle Cell Crises?
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cumulative Opioid Dosing |
.2; .2 | — |
| SECONDARY Pain Scores |
5.5; 5.2 | — |
| SECONDARY Inpatient Admission |
25; 21 | — |
| SECONDARY Adverse Effects |
0; 0 | — |
| SECONDARY Percentage of the Patients Reporting Satisfaction |
84; 85 | — |
Eligibility Criteria
Inclusion Criteria
- Any patient age 4-16 years with sickle cell disease who presents the Pediatric ER with acute sickle cell pain crisis with a pain of 6/10 or higher
Exclusion Criteria
- Patient with fever (38C or 100.4F)
- Patient less than age 4 years
- Patient greater than age 16 years
- Patient with hypersensitivity/allergy to either morphine, NSAIDs, or acetaminophen
- Patient received acetaminophen within the past 4 hours
- Patient with known liver disease or renal disease
- Patient not requiring IV morphine (pain score 5/10 or less)
- Patient enrolled in the study within the past 72 hours
Data sourced from ClinicalTrials.gov (NCT03541980) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.