Phase 4
N=428
Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation
Intubation Complication
Bottom Line
View on ClinicalTrials.gov: NCT03545503 ↗Enrolled (actual)
428
Serious AEs
0.3%
Results posted
Nov 2021
Primary outcome: Primary: Hemodynamic Effect as Measured by Systolic Blood Pressure Before and After RSI — 138.04; 132.39; 139.09; 130.09 mmHg
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Etomidate (Drug); Ketamine (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- South East Area Health Education Center, Wilmington, NC
- Primary completion
- Sep 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Hemodynamic Effect as Measured by Systolic Blood Pressure Before and After RSI |
138.04; 132.39; 139.09; 130.09; 130.42; 120.80 | — |
Summary
The purpose of this study is to compare the hemodynamic effects of ketamine v etomidate during rapid sequence intubation (RSI) in the pre-hospital and emergency department setting.
Eligibility Criteria
Inclusion Criteria
- Persons greater than 18yrs requiring rapid sequence intubation for any reason.
Exclusion Criteria
- Pregnant patients
- Children under the age of 18
- Patients with a known hypersensitivity to etomidate or ketamine
Data sourced from ClinicalTrials.gov (NCT03545503). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.